TY  - JOUR
A1  - Behl, Marc
A1  - Zhao, Qian
A1  - Lendlein, Andreas
T1  - Glucose-responsive shape-memory cryogels
T2  - Journal of materials research : JMR
N2  - Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C-glu varied between 0 and 300 mg/dL. In bending experiments, shape fixity R-f approximate to 80% and shape recovery R-r approximate to 100% from five programming/recovery cycles could be determined. R-r was a function of C-glu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of C-glu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.
KW  - shape memory
KW  - polymer
KW  - porosity
Y1  - 2020
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/60061
SN  - 0884-2914
SN  - 2044-5326
VL  - 35
IS  - 18
SP  - 2396
EP  - 2404
PB  - Springer
CY  - Berlin
ER  -