TY  - JOUR
A1  - Wallmeyer, Leonie
A1  - Dietert, Kristina
A1  - Sochorova, Michaela
A1  - Gruber, Achim D.
A1  - Kleuser, Burkhard
A1  - Vavrova, Katerina
A1  - Hedtrich, Sarah
T1  - TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
T2  - Scientific reports
N2  - Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology. For example, thymic stromal lymphopoietin (TSLP) is highly expressed in lesional atopic skin and significantly contributes to the pathogenesis of AD by activating dendritic cells that then initiate downstream effects on, for example, T cells. However, little is known about the direct interplay between TSLP, filaggrin-deficient skin and other immune cells such as T lymphocytes. In the present study, FLG knockdown skin equivalents, characterised by intrinsically high TSLP levels, were exposed to activated CD4(+) T cells. T cell exposure resulted in an inflammatory phenotype of the skin equivalents. Furthermore, a distinct shift from a Th1/Th17 to a Th2/Th22 profile was observed following exposure of T cells to filaggrin-deficient skin equivalents. Interestingly, TSLP directly stimulated T cell migration exclusively in filaggrin-deficient skin equivalents even in the absence of dendritic cells, indicating a hitherto unknown role of TSLP in the pathogenesis of AD.
Y1  - 2017
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46733
SN  - 2045-2322
VL  - 7
PB  - Nature Publ. Group
CY  - London
ER  -