TY  - JOUR
A1  - Baesler, Jessica
A1  - Michaelis, Vivien
A1  - Stiboller, Michael
A1  - Haase, Hajo
A1  - Aschner, Michael
A1  - Schwerdtle, Tanja
A1  - Sturzenbaum, Stephen R.
A1  - Bornhorst, Julia
T1  - Nutritive manganese and zinc overdosing in aging c. elegans result in a metallothionein-mediated alteration in metal homeostasis
T2  - Molecular Nutrition and Food Research
N2  - Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study focuses on Mn-Zn-interactions in the nematode Caenorhabditis elegans (C. elegans) model, taking into account aspects related to aging and age-dependent neurodegeneration.
KW  - aging
KW  - C. elegans
KW  - homeostasis
KW  - manganese
KW  - zinc
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/51498
SN  - 1613-4133
SN  - 1613-4125
VL  - 65
IS  - 8
SP  - 1
EP  - 11
PB  - Wiley-VCH GmbH
CY  - Weinheim
ER  -