TY  - JOUR
A1  - Tebaldi, Marli Luiza
A1  - Charan, Himanshu
A1  - Mavliutova, Liliia
A1  - Böker, Alexander
A1  - Glebe, Ulrich
T1  - Dual-Stimuli Sensitive Hybrid Materials: Ferritin-PDMAEMA by Grafting-From Polymerization
T2  - Macromolecular chemistry and physics
N2  - The combination of stimuli-responsive polymers and proteins that can transport drugs is a promising approach for drug delivery. The formation of ferritin-poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) conjugates by atom-transfer radical polymerization from the protein macroinitiator is described. PDMAEMA is a dual-stimuli-responsive polymer and the thermo- and pH-responsive properties of the resulting conjugates are studied in detail with dynamic light scattering (DLS). Additionally, it is demonstrated that the lower critical solution temperature (LCST) of the protein-polymer conjugates can be further adjusted by the ionic strength of the solution. The conjugates are also characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), matrix-assisted laser desorption ionization-time of flight (MALDI-ToF) mass spectrometry, and NMR spectroscopy. The obtained MALDI-ToF mass spectra are exceptional for protein-polymer conjugates and have not been so often reported.
KW  - grafting-from
KW  - MALDI-ToF MS
KW  - polymerization
KW  - proteins
KW  - responsivity
Y1  - 2017
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46621
SN  - 1022-1352
SN  - 1521-3935
VL  - 218
PB  - Wiley-VCH
CY  - Weinheim
ER  -