TY  - JOUR
A1  - Lau, Skadi
A1  - Liu, Yue
A1  - Maier, Anna
A1  - Braune, Steffen
A1  - Gossen, Manfred
A1  - Neffe, Axel T.
A1  - Lendlein, Andreas
T1  - Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation
T2  - MRS communications / a publication of the Materials Research Society
N2  - In vitro thrombogenicity test systems require co-cultivation of endothelial cells and platelets under blood flow-like conditions. Here, a commercially available perfusion system is explored using plasma-treated cyclic olefin copolymer (COC) as a substrate for the endothelial cell layer. COC was characterized prior to endothelialization and co-cultivation with platelets under static or flow conditions. COC exhibits a low roughness and a moderate hydrophilicity. Flow promoted endothelial cell growth and prevented platelet adherence. These findings show the suitability of COC as substrate and the importance of blood flow-like conditions for the assessment of the thrombogenic risk of drugs or cardiovascular implant materials.
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/64124
SN  - 2159-6867
VL  - 11
IS  - 5
SP  - 559
EP  - 567
PB  - Springer
CY  - Berlin
ER  -