TY  - GEN
A1  - Ferenz, Hans-Jörg
A1  - Peter, Martin G.
T1  - The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts
N2  - The antibiotic fungal metabolite sinefungin is a potent inhibitor of S-adenosylmethionine-acceptor methyltransferases. Its effect on insect metabolism and especially on corpora allata farnesoic acid methyltransferase, which catalyzes the penultimate step of juvenile hormone biosynthesis, was investigated in Locusta migratoria. Injection of sinefungin results in a delay of imaginal molt and in suppression of ovary development. Isolated corpora allata are unable to synthesize juvenile hormone III in the presence of more than 1.0 mM sinefungin. In a cell-free system containing the S-adenosylmethionine-dependent farnesoic acid methyltransferase from corpora allata sinefungin is a competitive inhibitor of the synthesis of methylfarnesoate with Ki of 1 μM.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 076 
KW  - Locust
KW  - sinefungin
KW  - O-methyltransferase
KW  - juvenile hormone biosynthesis
Y1  - 2008
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/1836
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:517-opus-16811
ER  -