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In this paper we report on our experiments in teaching computer science concepts with a mix of tangible and abstract object manipulations. The goal we set ourselves was to let pupils discover the challenges one has to meet to automatically manipulate formatted text. We worked with a group of 25 secondary school pupils (9-10th grade), and they were actually able to “invent” the concept of mark-up language. From this experiment we distilled a set of activities which will be replicated in other classes (6th grade) under the guidance of maths teachers.
A method is presented of acquiring the principles of three sorting algorithms through developing interactive applications in Excel.
Schutz und Schaden
(2023)
Viele Studieneingangs- und Eignungstests haben zum Ziel, für den entsprechenden Studiengang geeignete Studierende zu finden, die das Studium erfolgreich beenden können. Gerade in der Informatik ist aber häufig unklar, welche Eigenschaften geeignete Studierende haben sollten – auch stimmen mutmaßlich nicht alle Dozierenden in ihren Erwartungen an Studienanfänger*innen überein; Untersuchungen hierzu fehlen jedoch bislang. Um die Erwartungen von Dozent*innen an Studienanfänger*innen im Fach Informatik an deutschen Hochschulen zu analysieren, hat das Projekt MINTFIT im Sommer 2019 eine deutschlandweite Online-Befragung durchgeführt, an der 588 Hochschuldozent* innen aus allen Bundesländern teilnahmen. Die Umfrage hat gezeigt, dass überwiegend allgemeine Fähigkeiten, wie Motivation und logisches Denkvermögen, und nur wenig fachliches Vorwissen, wie Programmieren oder Formale Sprache, erwartet wird. Nach Einschätzung der Dozent*innen sind die problembehafteten Bereiche überwiegend in der theoretischen Informatik und in formellen Aspekten (z. B. Formale Sprache) zu finden. Obwohl Tendenzen erkennbar sind, zeigt die Umfrage, dass bei Anwendung strenger Akzeptanzkriterien keine Fähigkeiten und Kenntnisse explizit vorausgesetzt werden, was darauf hindeutet, dass noch kein deutschlandweiter Konsens unter den Lehrenden vorhanden ist.
Cargo transport by molecular motors is ubiquitous in all eukaryotic cells and is typically driven cooperatively by several molecular motors, which may belong to one or several motor species like kinesin, dynein or myosin. These motor proteins transport cargos such as RNAs, protein complexes or organelles along filaments, from which they unbind after a finite run length. Understanding how these motors interact and how their movements are coordinated and regulated is a central and challenging problem in studies of intracellular transport. In this thesis, we describe a general theoretical framework for the analysis of such transport processes, which enables us to explain the behavior of intracellular cargos based on the transport properties of individual motors and their interactions. Motivated by recent in vitro experiments, we address two different modes of transport: unidirectional transport by two identical motors and cooperative transport by actively walking and passively diffusing motors. The case of cargo transport by two identical motors involves an elastic coupling between the motors that can reduce the motors’ velocity and/or the binding time to the filament. We show that this elastic coupling leads, in general, to four distinct transport regimes. In addition to a weak coupling regime, kinesin and dynein motors are found to exhibit a strong coupling and an enhanced unbinding regime, whereas myosin motors are predicted to attain a reduced velocity regime. All of these regimes, which we derive both by analytical calculations and by general time scale arguments, can be explored experimentally by varying the elastic coupling strength. In addition, using the time scale arguments, we explain why previous studies came to different conclusions about the effect and relevance of motor-motor interference. In this way, our theory provides a general and unifying framework for understanding the dynamical behavior of two elastically coupled molecular motors. The second mode of transport studied in this thesis is cargo transport by actively pulling and passively diffusing motors. Although these passive motors do not participate in active transport, they strongly enhance the overall cargo run length. When an active motor unbinds, the cargo is still tethered to the filament by the passive motors, giving the unbound motor the chance to rebind and continue its active walk. We develop a stochastic description for such cooperative behavior and explicitly derive the enhanced run length for a cargo transported by one actively pulling and one passively diffusing motor. We generalize our description to the case of several pulling and diffusing motors and find an exponential increase of the run length with the number of involved motors.