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- chronic kidney disease (8)
- clefts (8)
- climate impacts (8)
- climate variability (8)
- convection (8)
- coronary artery disease (8)
- cortisol (8)
- cytotoxicity (8)
- data integration (8)
- data profiling (8)
- density functional calculations (8)
- diet (8)
- digital health (8)
- dissociative electron attachment (8)
- efficiency (8)
- electrospinning (8)
- energy policy (8)
- executive functions (8)
- food web (8)
- force (8)
- forest management (8)
- fractional Brownian motion (8)
- frequency (8)
- gamma-rays: galaxies (8)
- genetics (8)
- geophysics (8)
- graphene (8)
- grazing (8)
- hypertension (8)
- identity (8)
- imaging (8)
- immigration (8)
- inclusion (8)
- injury risk (8)
- instability (8)
- insurance (8)
- integration (8)
- intelligence (8)
- international organizations (8)
- ionic liquid (8)
- isomerization (8)
- isometric muscle action (8)
- land use change (8)
- landscape of fear (8)
- light (8)
- major depressive disorder (8)
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- mathematische Modellierung (8)
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- mechanobiology (8)
- membrane (8)
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- microscopy (8)
- microstructure (8)
- morphological processing (8)
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- neuroplasticity (8)
- noise (8)
- numerical relativity (8)
- numerical simulation (8)
- outflows (8)
- pain (8)
- parliamentary government (8)
- persistence (8)
- phosphorylation (8)
- plankton (8)
- plasmonics (8)
- polarization (8)
- polyelectrolyte (8)
- productivity (8)
- professional development (8)
- pronouns (8)
- proteomics (8)
- public administration (8)
- quality (8)
- quantification (8)
- quantum dots (8)
- quasars: general (8)
- race (8)
- reanalysis (8)
- rehabilitation (8)
- representation (8)
- residual stress (8)
- resources (8)
- restoration (8)
- risk perception (8)
- rotation (8)
- sedimentary ancient DNA (8)
- seed dispersal (8)
- selection (8)
- sexual scripts (8)
- signal transduction (8)
- snow (8)
- social inclusion (8)
- soil (8)
- spatial frequencies (8)
- starch metabolism (8)
- stars: activity (8)
- stars: emission-line, Be (8)
- stars: kinematics and dynamics (8)
- surface chemistry (8)
- surface modification (8)
- suspended sediment (8)
- sustainable development (8)
- time series (8)
- time-series (8)
- treeline (8)
- trends (8)
- ultrafast (8)
- urbanization (8)
- ventral striatum (8)
- virtual reality (8)
- vitamin A (8)
- water quality (8)
- ADHD (7)
- Anisotropy (7)
- Anisotropy effect (7)
- Apoptosis (7)
- Aromaticity (7)
- Austria (7)
- BMI (7)
- C. elegans (7)
- COVID-19 pandemic (7)
- Capsella (7)
- Central Europe (7)
- Competition (7)
- Complex networks (7)
- Connectivity (7)
- Conversation Analysis (7)
- Crustal structure (7)
- Cytotoxicity (7)
- DNA damage (7)
- DNA radiation damage (7)
- Decision-making (7)
- Dirac operator (7)
- E. coli (7)
- Earthquake hazards (7)
- East African Rift System (7)
- Eutrophication (7)
- Fokus (7)
- Forschungsprojekte (7)
- Fredholm property (7)
- Future SOC Lab (7)
- Galaxien (7)
- Gender (7)
- Geochemistry (7)
- Geologie (7)
- Geschäftsprozessmanagement (7)
- Global change (7)
- Gravitationswellen (7)
- Greenland (7)
- Hertzsprung-Russell and C-M diagrams (7)
- Higher education (7)
- In-Memory Technologie (7)
- Indian Summer Monsoon (7)
- Interoception (7)
- Judaism (7)
- Kalman filter (7)
- LCSM (7)
- Leguminosae (7)
- LiDAR (7)
- Longitudinal study (7)
- Mekong Delta (7)
- Molecular dynamics (7)
- Molecularly imprinted polymers (7)
- Molybdenum cofactor (7)
- Monsoon (7)
- Monsun (7)
- Multicore Architekturen (7)
- Muscle strength (7)
- Netzwerke (7)
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- Palaeoclimate (7)
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- Protein (7)
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- RIXS (7)
- Remote sensing (7)
- Ring current effect (7)
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- Seesedimente (7)
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- Soil moisture (7)
- Solanaceae (7)
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- Sprachverarbeitung (7)
- Starch metabolism (7)
- Subduktion (7)
- Survey (7)
- Svalbard (7)
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- TAVI (7)
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- Unsicherheit (7)
- Unsicherheiten (7)
- Vesikel (7)
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- acquisition (7)
- adolescent (7)
- aggregation (7)
- air pollution (7)
- allostatic load (7)
- amygdala (7)
- arctic (7)
- arithmetic (7)
- articulation (7)
- bicameralism (7)
- binaries: eclipsing (7)
- birth weight (7)
- bystander (7)
- cAMP (7)
- calibration (7)
- catalogs (7)
- cell adhesion (7)
- charge generation (7)
- chemistry (7)
- chemotaxis (7)
- child (7)
- circadian clock (7)
- circulation (7)
- circumstellar matter (7)
- cities (7)
- climate-change mitigation (7)
- cluster expansion (7)
- coastal erosion (7)
- community (7)
- community ecology (7)
- comparison (7)
- complex systems (7)
- complexes (7)
- control (7)
- cyber aggression (7)
- defense (7)
- density (7)
- dietary patterns (7)
- discrepancy principle (7)
- distribution (7)
- duplicate detection (7)
- dust (7)
- ecological modelling (7)
- ecosystem functioning (7)
- energy (7)
- energy storage (7)
- ensemble Kalman filter (7)
- enzyme (7)
- enzyme catalysis (7)
- experiments (7)
- extinction (7)
- extraction (7)
- extreme rainfall (7)
- films (7)
- first passage time (7)
- flood (7)
- flow (7)
- fluorescence microscopy (7)
- food webs (7)
- function (7)
- functional magnetic resonance imaging (7)
- galaxies (7)
- galaxies: dwarf (7)
- galaxies: starburst (7)
- gender differences (7)
- gene flow (7)
- geochemistry (7)
- globalization (7)
- grain size (7)
- habitat (7)
- heart (7)
- heterogeneous catalysis (7)
- holocene (7)
- home range (7)
- human impact (7)
- imaging spectroscopy (7)
- immobilization (7)
- inference (7)
- infrared: stars (7)
- insect (7)
- institutions (7)
- insula (7)
- interoceptive awareness (7)
- isotopes (7)
- jumping (7)
- kinematics (7)
- land-use change (7)
- last glacial maximum (7)
- lipid metabolism (7)
- low-energy electrons (7)
- malnutrition (7)
- measurement (7)
- mechanisms (7)
- memory retrieval (7)
- metaanalysis (7)
- metabolite profiling (7)
- methane (7)
- microbial ecology (7)
- microtubules (7)
- minerals (7)
- mobility (7)
- modality (7)
- multilingualism (7)
- muscle (7)
- natural language processing (7)
- natural products (7)
- neuromuscular control (7)
- neutron diffraction (7)
- nuclear lamina (7)
- numerical simulations (7)
- organic matter (7)
- organic photovoltaics (7)
- orthography (7)
- oscillations (7)
- pH (7)
- palaeoecology (7)
- paleoecology (7)
- parafoveal processing (7)
- parameter estimation (7)
- pathogens (7)
- perceptual span (7)
- perturbation (7)
- phase transition (7)
- phase transitions (7)
- photoelectron spectroscopy (7)
- planetary nebulae: general (7)
- planets and satellites: rings (7)
- plant diversity (7)
- policy (7)
- pollution (7)
- porous materials (7)
- predator-prey dynamics (7)
- presidential government (7)
- preview benefit (7)
- production control (7)
- pronoun resolution (7)
- prosodic boundary cues (7)
- proteasome (7)
- pulsars: general (7)
- radiocarbon (7)
- recombination (7)
- repair (7)
- reproducibility (7)
- retinol (7)
- rheology (7)
- roughness (7)
- scattering (7)
- secular trend (7)
- seismic hazard (7)
- selenium (7)
- shape-memory effect (7)
- sharing economy (7)
- silicon (7)
- size (7)
- social rejection (7)
- solar cells (7)
- solar wind (7)
- sorption (7)
- stabile Isotope (7)
- standardization (7)
- stars: late-type (7)
- sunspots (7)
- surfactants (7)
- surveillance (7)
- tVNS (7)
- techniques: image processing (7)
- thermokarst (7)
- tomography (7)
- transfer (7)
- transition (7)
- trunk (7)
- ultrafast dynamics (7)
- verification (7)
- visualization (7)
- water management (7)
- weather (7)
- wh-in-situ (7)
- wh-questions (7)
- working memory capacity (7)
- yellow flags (7)
- youth sports (7)
- AFM (6)
- Adipositas (6)
- Ageing (6)
- Alaska (6)
- Alps (6)
- Anpassung (6)
- Antibiotikaresistenz (6)
- Aphasie (6)
- Arbeitsgedächtnis (6)
- Arsenolipids (6)
- Assessment (6)
- Atmosphäre (6)
- Bakterien (6)
- Balance (6)
- Bayesian data analysis (6)
- Bewegungsökologie (6)
- Big Data (6)
- Bioelectrocatalysis (6)
- Biogenic amine (6)
- Biophysik (6)
- Blockcopolymere (6)
- C-reactive protein (6)
- CO2 (6)
- Chytridiomycota (6)
- Click chemistry (6)
- Colombia (6)
- Computational modelling (6)
- Coping (6)
- Copper (6)
- Cystic fibrosis (6)
- Data assimilation (6)
- Deep learning (6)
- Design (6)
- Design Thinking (6)
- Dezentralisierung (6)
- Digitalisierung (6)
- Disturbance (6)
- Dynamic NMR (6)
- EEG/ERP (6)
- East Germany (6)
- Electrical conductivity (6)
- Emotions (6)
- Energy (6)
- European hare (6)
- Flood risk (6)
- Fluorescence spectroscopy (6)
- GIS (6)
- Gammastrahlungsastronomie (6)
- Gene-environment interaction (6)
- Genomics (6)
- Geomorphology (6)
- Geophysik (6)
- Groundwater (6)
- H II regions (6)
- HIREC (6)
- ISM: kinematics and dynamics (6)
- Induced seismicity (6)
- Insurance (6)
- Interaction (6)
- Interest (6)
- Israel (6)
- Japan (6)
- Klimaänderung (6)
- Künstliche Intelligenz (6)
- Lake Van (6)
- Land use change (6)
- Language acquisition (6)
- Lasers (6)
- Levy flights (6)
- Local Group (6)
- Longitudinal (6)
- Lysiphlebus fabarum (6)
- Magnetismus (6)
- Magnetohydrodynamik (6)
- Mandarin Chinese (6)
- Massenspektrometrie (6)
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- Meta-analysis (6)
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- Modell (6)
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- Movement (6)
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- Navier-Stokes equations (6)
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- O-antigen (6)
- Oxygen heterocycles (6)
- PBPK (6)
- PUFA (6)
- Paleolimnology (6)
- Pavlovian-to-instrumental transfer (6)
- Perception (6)
- Perceptual span (6)
- Phenotypic plasticity (6)
- Phonons (6)
- Photosynthese (6)
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- Prevalence (6)
- Priming (6)
- Prozessmodellierung (6)
- Prunus avium L. (6)
- Pyrenees (6)
- Quasare (6)
- R&D (6)
- Raman (6)
- Reinforcement learning (6)
- Reliability (6)
- Resistance training (6)
- Return to work (6)
- Rheologie (6)
- Rheology (6)
- SDS-PAGE (6)
- Schadensmodellierung (6)
- Second World War (6)
- Seismic tomography (6)
- Seismology (6)
- Self-paced reading (6)
- Sentinel-1 (6)
- Sexual scripts (6)
- Sexual selection (6)
- Smalltalk (6)
- Soil erosion (6)
- Speech perception (6)
- Sphingosine 1-phosphate (6)
- Stable isotopes (6)
- Sternentwicklung (6)
- Stretch-shortening cycle (6)
- Subduction zone processes (6)
- Synthesis (6)
- TMS (6)
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- Westerlies (6)
- Wind erosion (6)
- Zinc (6)
- acid ceramidase (6)
- administration (6)
- admixture (6)
- age of acquisition (6)
- agreement (6)
- alexithymia (6)
- algorithms (6)
- alignment (6)
- amino acids (6)
- animal movement (6)
- anthropometry (6)
- antibody (6)
- antioxidants (6)
- apoptosis (6)
- attitudes (6)
- bias (6)
- big data (6)
- biodegradable polymers (6)
- black holes (6)
- brain (6)
- bryophytes (6)
- business processes (6)
- carbon dioxide (6)
- cardiorespiratory fitness (6)
- cartel (6)
- change (6)
- change detection (6)
- characteristics (6)
- chemical modification (6)
- chloroplast (6)
- co-limitation (6)
- coherence (6)
- collusion (6)
- colonialism (6)
- community effect (6)
- conversation analysis (6)
- corruption (6)
- costs (6)
- crown compounds (6)
- crystal-structure (6)
- cyber victimization (6)
- cyber-physical systems (6)
- cytoskeleton (6)
- data (6)
- databases (6)
- depressive symptoms (6)
- diabetic nephropathy (6)
- dielectrophoresis (6)
- diffuse radiation (6)
- digital education (6)
- domestication (6)
- droughts (6)
- dust, extinction (6)
- dyslexia (6)
- early warning (6)
- eclogite (6)
- ecohydrology (6)
- effectiveness (6)
- efficient (6)
- eicosapentaenoic acid (6)
- electrons (6)
- electrostatic interactions (6)
- elementary particles (6)
- engagement (6)
- english (6)
- entropy (6)
- environmental change (6)
- enzymes (6)
- exercise therapy (6)
- extension (6)
- fNIRS (6)
- fabrication (6)
- facilitation (6)
- fertilization (6)
- first passage (6)
- first-passage time (6)
- floodplain (6)
- fluorescence correlation spectroscopy (6)
- formal semantics (6)
- galaxies: abundances (6)
- galaxy evolution (6)
- gamma-ray astronomy (6)
- gamma-rays: general (6)
- gas (6)
- gelatin (6)
- general relativity (6)
- genes (6)
- geodynamics (6)
- geology (6)
- geometric Brownian motion (6)
- giving-up density (6)
- global (6)
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- grammar (6)
- gravity (6)
- habituation (6)
- heat stress (6)
- heterocycles (6)
- history and philosophy of astronomy (6)
- holding capacity (6)
- hybridization capture (6)
- hydrolysis (6)
- impacts (6)
- infancy (6)
- infection (6)
- injury (6)
- interfaces (6)
- introgression (6)
- invasive species (6)
- kosmische Strahlung (6)
- leadership (6)
- life history (6)
- linagliptin (6)
- lithosphere (6)
- macrophytes (6)
- magnetism (6)
- mapping (6)
- maturation (6)
- meaning (6)
- mechanism (6)
- media violence (6)
- melt inclusions (6)
- mental simulation (6)
- metabolic networks (6)
- metabolites (6)
- methods: analytical (6)
- miRNA (6)
- micelles (6)
- microbial communities (6)
- microbial diversity (6)
- mixed methods (6)
- molecular modeling (6)
- molecular motors (6)
- muscle power (6)
- neotectonics (6)
- neurodegeneration (6)
- next generation sequencing (6)
- non-fullerene acceptors (6)
- nonergodicity (6)
- nuclear envelope (6)
- nucleus (6)
- numerical development (6)
- organization (6)
- overweight (6)
- oxygen (6)
- p53 (6)
- palaeoclimate (6)
- parameters (6)
- participation (6)
- pattern formation (6)
- phenology (6)
- phonetics (6)
- phosphate (6)
- phylogenetic diversity (6)
- piezoelectricity (6)
- plant (6)
- plants (6)
- plyometric training (6)
- political equality (6)
- polyelectrolytes (6)
- polystyrene (6)
- polyzwitterions (6)
- population density (6)
- porosity (6)
- porous carbon (6)
- postural stability (6)
- pregnancy (6)
- programming (6)
- projections (6)
- propensity score matching (6)
- protection (6)
- protein-protein interaction (6)
- public management (6)
- racism (6)
- radical polymerization (6)
- rainfall (6)
- rat (6)
- reciprocal class (6)
- reconstruction (6)
- reduction (6)
- reflection (6)
- reproduction (6)
- retinol-binding protein 4 (6)
- risk factor (6)
- running (6)
- saccades (6)
- salinity gradient (6)
- salivary gland (6)
- scale development (6)
- scrambling (6)
- sedaDNA (6)
- sediment transport (6)
- self-concept (6)
- self-healing (6)
- self-regulation (6)
- sensitivity analysis (6)
- silver nanoparticles (6)
- soccer (6)
- social comparison (6)
- socioeconomic status (6)
- sodium (6)
- software engineering (6)
- speciation (6)
- spectra (6)
- speed (6)
- star formation (6)
- stars: horizontal-branch (6)
- stars: magnetic fields (6)
- stimuli-sensitive polymers (6)
- stroke (6)
- sulfite oxidase (6)
- support vector machine (6)
- teaching (6)
- thaliana (6)
- therapist competence (6)
- thermoresponsive polymers (6)
- tomato (6)
- topography (6)
- tracking (6)
- trade-offs (6)
- training adaptation (6)
- traits (6)
- transcriptional memory (6)
- trust (6)
- tundra (6)
- uncertainty analysis (6)
- unemployment (6)
- uplift (6)
- user experience (6)
- variation (6)
- violence (6)
- visions of democracy (6)
- walking (6)
- weight loss (6)
- wetlands (6)
- women (6)
- world literature (6)
- zebrafish (6)
- 3D point clouds (5)
- 3D visualization (5)
- AC electrokinetics (5)
- ALAN (5)
- ARPES (5)
- Absorption (5)
- Ackerschmalwand (5)
- African Humid Period (5)
- Aftercare (5)
- Age of acquisition (5)
- Agency (5)
- Air pollution (5)
- Algeria (5)
- Alterung (5)
- Amygdala (5)
- Ancient DNA (5)
- Animal personality (5)
- Antwortmengenprogrammierung (5)
- Arctic lakes (5)
- Arsenic-containing hydrocarbons (5)
- Asian monsoon (5)
- Asteraceae (5)
- Autocorrelation (5)
- Basketball (5)
- Bayesian inversion (5)
- Big Five (5)
- Bilingualism (5)
- Biodiversity Exploratories (5)
- Biodiversity exploratories (5)
- Biofilm (5)
- Bioinformatik (5)
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- Block copolymers (5)
- Blockcopolymer (5)
- Blood (5)
- Bodenfeuchte (5)
- Body composition (5)
- Boric acid (5)
- Boron exposure (5)
- Bose-Einstein condensation (5)
- Brandenburg (5)
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- Cardiovascular diseases (5)
- Caribbean (5)
- Cattle (5)
- Cayley Graph (5)
- Cell polarity (5)
- Child (5)
- Chitooligosaccharides (5)
- Chloroplast (5)
- Cognitive control (5)
- Cold War (5)
- Community assembly (5)
- Computational seismology (5)
- Conservation (5)
- Cost-effectiveness (5)
- Cue-based retrieval (5)
- Cultural diversity (5)
- Cyanobakterien (5)
- DRD4 (5)
- Data profiling (5)
- Datenassimilation (5)
- Datenbank (5)
- Decision making (5)
- Dexamethasone (5)
- Dictyostelium discoideum (5)
- Duplikaterkennung (5)
- EPR (5)
- ERA5 (5)
- EU (5)
- Earthquake dynamics (5)
- Earthquake interaction (5)
- Ecotoxicology (5)
- Electropolymerization (5)
- Ellenberg indicator values (5)
- Elliptic complexes (5)
- Embodiment (5)
- Emulsion (5)
- Entwicklung (5)
- Environmental sciences (5)
- Europa (5)
- Europäische Union (5)
- Extraction (5)
- Extreme events (5)
- Eye movement (5)
- Feature selection (5)
- Fetal programming (5)
- Fire-bellied toad (5)
- Flood (5)
- Flow cytometry (5)
- Fluorescence imaging (5)
- Fokker-Planck equation (5)
- Food quality (5)
- Frailty (5)
- Free Group (5)
- Functional ankle instability (5)
- G-protein-coupled receptor (5)
- Galaxy: center (5)
- Geodynamik (5)
- Geomagnetic field (5)
- Geomagnetism (5)
- Geostatistics (5)
- German colonialism (5)
- Glucose (5)
- Gold nanoparticles (5)
- Governance (5)
- Graph theory (5)
- Grassland (5)
- Ground reaction force (5)
- HVSR (5)
- Habitat fragmentation (5)
- Heart rate variability (5)
- Hebrew (5)
- Heterocycles (5)
- Holding isometric muscle action (5)
- Hypertension (5)
- IAT (5)
- IR-MALDI (5)
- ISM: jets and outflows (5)
- ISM: lines and bands (5)
- ISM: magnetic fields (5)
- Imaging (5)
- Individual-based models (5)
- Information (5)
- Insect (5)
- Intervention (5)
- Ionosphere (5)
- Janus emulsions (5)
- Jugendliche (5)
- Kant (5)
- Kinder (5)
- Klimapolitik (5)
- Kosmologie (5)
- L2 processing (5)
- LC–MS/MS (5)
- Lactams (5)
- Lactones (5)
- Lakes (5)
- Land-use intensity (5)
- Landslides (5)
- Langmuir monolayer (5)
- Language production (5)
- Larix (5)
- Late Holocene (5)
- Late Pleistocene (5)
- Late Quaternary (5)
- Leadership (5)
- Life history (5)
- Lonar Lake (5)
- MQTT (5)
- Magnetostratigraphy (5)
- Magnetotellurics (5)
- Magnetotellurik (5)
- Measurement (5)
- Mechanotendography (5)
- Mediterranean (5)
- Memory (5)
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- Städte (4)
- Sun (4)
- Supervision (4)
- Surface roughness (4)
- Surface waves and free oscillations (4)
- Survival (4)
- Swedish (4)
- Systems biology (4)
- TEM (4)
- TSNMRS (4)
- Teacher motivation (4)
- Teacher self-efficacy (4)
- Team sports (4)
- Telerehabilitation (4)
- Temperatur (4)
- Tenside (4)
- Thermal effects (4)
- Thermochronology (4)
- Thermoresponsive (4)
- ToF-SIMS (4)
- Toeplitz operators (4)
- Trace elements (4)
- Transkriptionsfaktor (4)
- Transkriptomik (4)
- Triassic (4)
- Tropical forest (4)
- Tso Moriri Lake (4)
- Turkish-German bilingualism (4)
- Türkisch (4)
- UAV (4)
- UNFCCC (4)
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- Ultrasound (4)
- Uncertainties (4)
- Underspecification (4)
- VIIRS DNB (4)
- Van Allen Probes (4)
- Variabilität (4)
- Vegetation change (4)
- Verification (4)
- Verwaltung (4)
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- Virus (4)
- WA-PLS (4)
- Weight (4)
- Weight bias internalization (4)
- West Africa (4)
- West Antarctica (4)
- West Bohemia (4)
- Wissensmanagement (4)
- Work ability (4)
- X-ray emission spectroscopy (4)
- X-ray scattering (4)
- X-rays (4)
- XRF (4)
- Xanthomonas (4)
- absorption (4)
- accretion (4)
- accretion, accretion disks (4)
- accuracy (4)
- achilles tendinopathy (4)
- action language (4)
- action processing (4)
- action words (4)
- actuation (4)
- adaptive force (4)
- additive particles (4)
- adherence (4)
- adipogenesis (4)
- adiponectin (4)
- adjectives (4)
- administrative reform (4)
- advanced dynamic flow (4)
- affective (4)
- agent-based model (4)
- agility (4)
- agreement attraction (4)
- aldehyde oxidase (4)
- allelopathy (4)
- anaphors (4)
- antifouling (4)
- antilocality (4)
- app (4)
- aptamers (4)
- aquatic ecosystems (4)
- aqueous-solution (4)
- arabidopsis (4)
- arabidopsis-thaliana (4)
- architecture (4)
- argumentation (4)
- arsenolipids present (4)
- association (4)
- astronomy (4)
- astrophysical plasmas (4)
- atherosclerosis (4)
- attachment (4)
- augmented reality (4)
- automatic evaluation (4)
- automatic evaluations (4)
- autonomy (4)
- autophagy (4)
- biodiversity exploratories (4)
- bioelectrocatalysis (4)
- biogeochemistry (4)
- biological age (4)
- bis-MGD (4)
- black hole physics (4)
- body composition (4)
- body image (4)
- brushes (4)
- brushite (4)
- bulk heterojunction (4)
- business (4)
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- capacity (4)
- carbon isotopes (4)
- carbon nitrides (4)
- carbon pricing (4)
- carbon sequestration (4)
- cardiomyopathy (4)
- catchments (4)
- categories (4)
- cell cycle (4)
- cell wall (4)
- cell-free protein synthesis (4)
- change management (4)
- charcoal (4)
- circular dichroism (4)
- citizenship (4)
- civil war (4)
- climate change impacts (4)
- climate extremes (4)
- climate warming (4)
- clinical sample (4)
- clone (4)
- cluster analysis (4)
- co-occurrence analysis (4)
- cod-liver (4)
- codon usage (4)
- coefficient (4)
- coevolution (4)
- cognitive enhancement (4)
- cognitive modeling (4)
- collaboration (4)
- collaborative consumption (4)
- collagen (4)
- colloids (4)
- colonization (4)
- color (4)
- combat sports (4)
- common vole (4)
- community structure (4)
- competence (4)
- compliance (4)
- composites (4)
- computer games (4)
- computer-based training (4)
- concepts (4)
- conceptualization (4)
- conduct problems (4)
- conductivity (4)
- confidence (4)
- confocal microscopy (4)
- conjugated polymers (4)
- content-addressable memory (4)
- context (4)
- contracts (4)
- conversational agents (4)
- convolutional neural network (4)
- coping strategies (4)
- copper(II) (4)
- core (4)
- coronary heart disease (4)
- corrosion (4)
- cosmic-ray neutron sensing (4)
- counting (4)
- covariance (4)
- creep (4)
- crop production (4)
- cross-cultural comparison (4)
- cross-national (4)
- crosslinking (4)
- cultural pluralism (4)
- cyberbullying victimization (4)
- cyclic voltammetry (4)
- cylindrospermopsin (4)
- cystic fibrosis (4)
- cytochrome c (4)
- data mining (4)
- data preparation (4)
- data quality (4)
- deep-sea (4)
- deforestation (4)
- deformation (4)
- degenerative disc disease (4)
- deposition (4)
- design (4)
- diabetes mellitus (4)
- dictator game (4)
- differentiation (4)
- digital (4)
- digital platforms (4)
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- disability (4)
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- diversification (4)
- dog (4)
- downscaling (4)
- dropout (4)
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- drugs (4)
- dual-process (4)
- dyadic coping (4)
- dye removal (4)
- dynamic (4)
- dynamical models (4)
- dynamical systems (4)
- e-government (4)
- eco-evolutionary experience (4)
- edge effect (4)
- effect (4)
- elections (4)
- electron paramagnetic resonance (4)
- electron-transfer (4)
- electrostatics (4)
- emissions (4)
- emotional expression (4)
- emulsion (4)
- emulsion polymerization (4)
- endophytes (4)
- enhancement (4)
- entanglement (4)
- entrepreneurship education (4)
- environmental filtering (4)
- environmental policy (4)
- equifinality (4)
- errata, addenda (4)
- ethnicity (4)
- evaluative study (4)
- evaporites (4)
- event-related brain potentials (4)
- evolutionary history (4)
- exercise intensity (4)
- experimental design (4)
- exploratory-behavior (4)
- eye-movement monitoring (4)
- face perception (4)
- fatty acid metabolism (4)
- fatty-acids (4)
- fault (4)
- feature selection (4)
- fence ecology (4)
- ferroelectric polymers (4)
- fiction (4)
- financial crisis (4)
- financial institutions (4)
- finger counting (4)
- fire (4)
- first language acquisition (4)
- first-passage (4)
- floral scent (4)
- flower development (4)
- fluctuating light (4)
- fluctuations (4)
- fluid inclusions (4)
- fluorescent dyes (4)
- food choice (4)
- forest (4)
- formal verification (4)
- fractional dynamics (4)
- framework (4)
- friendship (4)
- frustration (4)
- functional response (4)
- fundamental frequency (4)
- fungi (4)
- galaxies: star formation (4)
- garden-path effect (4)
- gaze-contingent displays (4)
- gene regulation (4)
- gene regulatory networks (4)
- genealogy (4)
- genetic diversity (4)
- genome-wide association (4)
- geomorphometry (4)
- geothermal energy (4)
- geovisualization (4)
- glaciers (4)
- global jets (4)
- global positioning system (4)
- global sensitivity analysis (4)
- glomerular filtration rate (4)
- glucose oxidation (4)
- glucosinolates (4)
- glutathione (4)
- grammaticalization (4)
- graph theory (4)
- graph transformation (4)
- graph transformation systems (4)
- graphs (4)
- green chemistry (4)
- ground reaction force (4)
- ground-penetrating radar (4)
- groundwater recharge (4)
- group field theory (4)
- gut microbiota (4)
- handgrip strength (4)
- handwriting (4)
- health care (4)
- healthcare (4)
- heat (4)
- helical magnetic fields (4)
- hemocompatibility (4)
- heritage language (4)
- heterostyly (4)
- heuristics (4)
- high-intensity interval training (4)
- historiography (4)
- holding isometric muscle action (HIMA) (4)
- honey bee (4)
- human rights (4)
- human-computer interaction (4)
- hybrid (4)
- hydrological modeling (4)
- hydrological models (4)
- hyporheic zone (4)
- immune system (4)
- immunoassay (4)
- immunology (4)
- implicit attitude (4)
- impulsivity (4)
- in vitro (4)
- in-situ (4)
- individual (4)
- inertial measurement unit (4)
- infinite-dimensional Brownian diffusion (4)
- insulin signaling (4)
- interactional linguistics (4)
- interception (4)
- interest (4)
- interference control (4)
- intergovernmental relations (4)
- international organisations (4)
- intersectionality (4)
- intrusion detection (4)
- inverse analysis (4)
- ionic conductivity (4)
- ionic strength (4)
- job satisfaction (4)
- joint Simon effect (4)
- joint action (4)
- karst (4)
- kernel methods (4)
- kidney transplantation (4)
- knickpoint (4)
- knowledge (4)
- komplexe Netzwerke (4)
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- lactate (4)
- land-use intensity (4)
- large-scale structure of Universe (4)
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- laterality (4)
- law (4)
- left periphery (4)
- lexical access (4)
- lexicon (4)
- lichens (4)
- life satisfaction (4)
- lifestyle (4)
- light variability (4)
- line: identification (4)
- linear hypersubstitution (4)
- lipopolysaccharide (4)
- loading rate (4)
- local time (4)
- locomotion (4)
- locus coeruleus (4)
- long-term effects (4)
- low-back-pain (4)
- lower critical solution temperature (4)
- machine (4)
- macrocycles (4)
- macrophages (4)
- magnetostriction (4)
- magnetotellurics (4)
- mammals (4)
- mass (4)
- mathematics instruction (4)
- meadow (4)
- measurement invariance (4)
- mechanical properties (4)
- mechanical tendinous oscillations (4)
- media (4)
- memory effects (4)
- mesenchymal stem cells (4)
- mesoporous materials (4)
- metabolic engineering (4)
- metabolic regulation (4)
- metadata (4)
- metagenomics (4)
- metaphor (4)
- meteorological drought (4)
- methanogenic archaea (4)
- methods: statistical (4)
- methyl orange (4)
- methylene blue (4)
- methylmercury (4)
- miRNAs (4)
- micro-CT (4)
- microRNA (4)
- microgels (4)
- micronutrients (4)
- mid-temperature transition (4)
- mild cognitive impairment (4)
- mitochondrial DNA (4)
- mixtures (4)
- mobile links (4)
- modular production (4)
- molecular evolution (4)
- molecules (4)
- moment tensor (4)
- monoclonal antibody (4)
- morphogenesis (4)
- muscle oxygen saturation (4)
- music information retrieval (4)
- myocardial infarction (4)
- n-alkanes (4)
- nachhaltige Chemie (4)
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- nanostructure (4)
- nanotriangles (4)
- narrative (4)
- nested graph conditions (4)
- network reconstruction (4)
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- neurotoxicity (4)
- neutrinos (4)
- new species (4)
- new technology (4)
- next generation sequencing (NGS) (4)
- non-alcoholic fatty liver disease (4)
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- non-photorealistic rendering (4)
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- nonlinear (4)
- nonlinear operator (4)
- numerical (4)
- numerical model (4)
- ocean (4)
- ocean acidification (4)
- ocean color remote sensing (4)
- online (4)
- online course creation (4)
- online course design (4)
- online discrimination (4)
- online learning (4)
- ontogeny (4)
- open data (4)
- open-circuit voltage (4)
- optimal foraging (4)
- optimal transport (4)
- optimization (4)
- organic carbon (4)
- organic chemistry (4)
- osmotic-pressure (4)
- osteoblast (4)
- other-race effect (4)
- outcomes (4)
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- palladium (4)
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- part 1 (4)
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- partial least squares (4)
- particle acceleration (4)
- pathway (4)
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- persulfide (4)
- phase oscillators (4)
- phenols (4)
- phenotyping (4)
- phonological awareness (4)
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- photofragmentation (4)
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- photoisomerization (4)
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- phototaxis (4)
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- physical performance (4)
- physics education (4)
- physiological consequences (4)
- phytolith (4)
- picture naming (4)
- picture-word interference (4)
- planetary rings (4)
- planets and satellites: atmospheres (4)
- plant cell wall (4)
- plant development (4)
- plant growth (4)
- plant population and community dynamics (4)
- plasma membrane (4)
- platelets (4)
- playa (4)
- plume (4)
- point process (4)
- policy-making (4)
- politeness (4)
- poly(ethylene glycol) (4)
- polyelectrolyte adsorption (4)
- polymer chemistry (4)
- polypropylene (4)
- polysemy (4)
- population structure (4)
- populations (4)
- pornography (4)
- poröse Materialien (4)
- power spectral analysis (4)
- pragmatics (4)
- pre-school (4)
- preactivation (4)
- precuneus (4)
- preference assessment (4)
- preschool children (4)
- pressure (4)
- principal component analysis (4)
- proactive aggression (4)
- proactivity (4)
- probabilistic timed systems (4)
- process (4)
- production (4)
- properties (4)
- protein engineering (4)
- protein modification (4)
- protein-protein interactions (4)
- proteinuria (4)
- proteome (4)
- psychological distress (4)
- psychosocial moderators (4)
- pubertal timing (4)
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- qualitative Analyse (4)
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- questionnaire (4)
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- radicals (4)
- rampage (4)
- random point processes (4)
- random walk (4)
- random walks (4)
- randomized controlled trial (4)
- rape myth acceptance (4)
- rare earth elements (4)
- rate of perceived exertion (4)
- reactive aggression (4)
- real-time (4)
- recollection (4)
- recombinant inbred line (4)
- recurrence (4)
- recurrence plot (4)
- redox state (4)
- reference (4)
- reforms (4)
- regime shift (4)
- regression (4)
- regularity (4)
- reionization (4)
- relatedness (4)
- remagnetization (4)
- replication (4)
- representation learning (4)
- reproductive strategies (4)
- reproductive success (4)
- research (4)
- research school (4)
- resistin (4)
- resonance energy transfer (4)
- reward anticipation (4)
- risk perceptions (4)
- risk reduction (4)
- river incision (4)
- rivers (4)
- robustness (4)
- rolling averages (4)
- root traits (4)
- rotifer (4)
- run time analysis (4)
- runners (4)
- rural (4)
- salivary alpha-amylase (4)
- salt (4)
- salt pan (4)
- sanctions (4)
- scaffolding (4)
- scenario (4)
- scenario analysis (4)
- scenarios (4)
- school adjustment (4)
- school children (4)
- school mathematics (4)
- school shooting (4)
- screening (4)
- sea level (4)
- secondary school (4)
- sedimentology (4)
- self-control (4)
- self-evaluation (4)
- self-objectification (4)
- self-sovereign identity (4)
- selfing syndrome (4)
- sensor (4)
- sentence reading (4)
- sequence (4)
- sexual assault (4)
- sexual coercion (4)
- sexual selection (4)
- sexual victimization (4)
- sexualization (4)
- shape (4)
- shape memory (4)
- shape-memory polymers (4)
- shrub encroachment (4)
- signal propagation (4)
- similarity measures (4)
- single nucleotide polymorphism (4)
- skill (4)
- skin (4)
- small mammals (4)
- smart contracts (4)
- social acceptance (4)
- social status (4)
- software (4)
- soils (4)
- space (4)
- space use (4)
- spatial (4)
- species distribution model (4)
- species distribution modelling (4)
- specific root length (4)
- spectral analysis (4)
- speech segmentation (4)
- spelling (4)
- stakeholder participation (4)
- stars: black holes (4)
- stars: distances (4)
- stars: low-mass (4)
- stars: oscillations (4)
- starspots (4)
- start-up subsidies (4)
- states (4)
- statins (4)
- statistical mechanics (4)
- statistical seismology (4)
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- sterols (4)
- stochastic analysis (4)
- stochastic process (4)
- storage (4)
- strain localization (4)
- stress response (4)
- stress tolerance (4)
- structure elucidation (4)
- subdiffusion (4)
- subjective well-being (4)
- subsidence (4)
- substance use (4)
- sucrose responsiveness (4)
- summer monsoon (4)
- supergene (4)
- supernova remnants (4)
- supernovae: general (4)
- supervisor support (4)
- surface relief grating (4)
- survey (4)
- sustainable chemistry (4)
- symbiosis (4)
- synchrotron radiation (4)
- synthetische Biologie (4)
- tandem solar cells (4)
- teacher beliefs (4)
- teacher learning (4)
- thermal (4)
- thermokarst lakes (4)
- thermoresponsiv (4)
- thiouracil (4)
- tocopherols (4)
- trade (4)
- trajectories (4)
- transcutaneous vagus nerve stimulation (4)
- transparency (4)
- treatment (4)
- trustworthiness (4)
- typology (4)
- ultrafast x-ray diffraction (4)
- ungulate (4)
- usability (4)
- value creation (4)
- vascular plants (4)
- verbs (4)
- vertical coupling (4)
- veterinary cordon fence (4)
- virtual machines (4)
- virus (4)
- virus infection (4)
- viscosity (4)
- visible-light (4)
- visual attention (4)
- vocabulary (4)
- voice (4)
- vowels (4)
- water fluxes (4)
- water security (4)
- water treatment (4)
- water-balance (4)
- water-soluble polymers (4)
- wave-particle interactions (4)
- wavelength (4)
- weak ergodicity breaking (4)
- web application (4)
- weight (4)
- weighted moving averages (4)
- wettability (4)
- wh-movement (4)
- willingness to intervene (4)
- working memory updating (4)
- workplace (4)
- xanthine dehydrogenase (4)
- yedoma (4)
- young adults (4)
- zebularine (4)
- 20. Jahrhundert (3)
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- 2D (3)
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- 2nd-language grammar (3)
- 3D Point Clouds (3)
- 3D city models (3)
- 3D geovisualization (3)
- 3D-Visualisierung (3)
- 4-nitrophenol (3)
- 5-methoxycarbonylmethyl-2-thiouridine (3)
- ABCB7 (3)
- AGN (3)
- AHP (3)
- ASIC (3)
- AUD (3)
- Abandonment (3)
- Abbau (3)
- Acacia mellifera (3)
- Academic achievement (3)
- Academic self-concept (3)
- Acer pseudoplatanus (3)
- Achilles and patellar tendon (3)
- Achilles tendon (3)
- Acid sphingomyelinase (3)
- Acquisition (3)
- Action processing (3)
- Acute coronary syndrome (3)
- Adam Smith (3)
- Additive manufacturing (3)
- Aerosol (3)
- Aerosole (3)
- Aesthetics (3)
- Affective Computing (3)
- African indigenous vegetables (3)
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- Agreement (3)
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- Alborz Mountains (3)
- Aldehyde oxidase (3)
- Aldehyde oxidoreductase (3)
- Aleatory variability (3)
- Algorithmen (3)
- Alkylpyridinium salts (3)
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- Alzheimer (3)
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- Approximate Bayesian Computation (3)
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- Attitude (3)
- Auger electron spectroscopy (3)
- August 2002 flood (3)
- Auxin transport (3)
- Azobenzene (3)
- Azobenzene containing cationic surfactants (3)
- BIAT (3)
- BIM (3)
- BL Lacertae objects: individual: Mrk 421 (3)
- BL Lacertae objects: individual: PKS 2155-304 (3)
- Bacteriophage (3)
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- Base pairing (3)
- Baseline shift (3)
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- prognosis (3)
- proliferation (3)
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- stars: (3)
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- ) (2)
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- 1 (2)
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- Potsdam Grievance Statistics File (PGSF) (2)
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- R (2)
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- Skin (2)
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- Small (2)
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- Small for gestational age (2)
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- Smoking (2)
- Smpd1 (2)
- Snow Cover Extent (SCE) (2)
- Sobo-Sise Island (2)
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- Sodium bicarbonate (2)
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- Spanish modal adverbs (2)
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- Spatial bias (2)
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- Speech Motor Control (2)
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- Speleothems (2)
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- Spitsbergen (2)
- Spitzbergen (2)
- Splicing (2)
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- Sprachkontakt (2)
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- Stochastic Differential Equation (2)
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- Stochastische Resonanz (2)
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- Strain (2)
- Strain measurement (2)
- Strategic growth adjustment (2)
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- Streuung (2)
- Strike-slip faults (2)
- Strong-motion (2)
- Stroop effect (2)
- Structural equation modeling (2)
- Structure-from-motion (2)
- Structuring (2)
- Strukturbildung (2)
- Student motivation (2)
- Sturm-Liouville problem (2)
- Style modification (2)
- Störungen (2)
- Subarctic North Pacific (2)
- Subject-verb agreement (2)
- Subjective well-being (2)
- Submarine permafrost (2)
- Submariner Permafrost (2)
- Subsampling (2)
- Subsea permafrost (2)
- Subsurface biosphere (2)
- Sulfate (2)
- Sulfite oxidase (2)
- Sulphoxide (2)
- Sumatra (2)
- Sun: UV radiation (2)
- Sun: heliosphere (2)
- Sun: magnetic topology (2)
- Sun: sunspots (2)
- Sundaland (2)
- Supernova remnants (2)
- Supernovae (2)
- Supernovaüberrest (2)
- Superoxide (2)
- Support (2)
- Supraleiter (2)
- Supramolecular chemistry (2)
- Surface (2)
- Surface composition (2)
- Surface exudates (2)
- Surface functionalization (2)
- Surface relief grating (2)
- Surface treatment (2)
- Surgical and invasive medical procedures (2)
- Survey Research Methods (2)
- Sustainable (2)
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- Sway (2)
- Swimming performance (2)
- Syllabic tone (2)
- Syllables (2)
- Synchronisierung (2)
- Synchronization control (2)
- Synchrotron (2)
- Synchrotronstrahlung (2)
- Syntax-semantics interface (2)
- Synthesis and processing (2)
- Syria (2)
- SysML (2)
- Systematic reviews (2)
- Säugetiere (2)
- Säuglinge (2)
- Südafrika (2)
- Südamerika (2)
- Südkorea (2)
- TACC (2)
- TAM (2)
- TDR (2)
- TELEMAC-2D model (2)
- TGF-beta 1 (2)
- TIG-welding (2)
- TIN (2)
- TLR signaling (2)
- TMR (2)
- TPACK (2)
- TRLFS (2)
- TRP channels (2)
- TRPC6 (2)
- TRPV1 (2)
- Taft equation (2)
- Tailspike (2)
- Taiwan (2)
- Takab (2)
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- Teacher beliefs (2)
- Teacher educator (2)
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- Teachers (2)
- Technical enzymes (2)
- Technologiebewertung (2)
- Tectonic Evolution (2)
- Tectonic stress (2)
- Temperate forest (2)
- Temperature reconstruction (2)
- Temperature-memory effect (2)
- Temporallogik (2)
- Tendons (2)
- Tenebrio molitor larvae (2)
- Tense (2)
- Tensid (2)
- Tephrosia purpurea (2)
- Terrestrial Si cycle (2)
- Test-Retest Reliability (2)
- Test-retest (2)
- Testen (2)
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- Text difficulty (2)
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- Thiomersal (2)
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- Ti4O7 (2)
- TiO2 nanoparticles (2)
- Tianshan orogenic belt (2)
- Tibet Plateau (2)
- Tibetan plateau (2)
- Tiefer See (2)
- Tight integration (2)
- Tikhonov regularization (2)
- Time of flight (2)
- Time series data (2)
- Time to task failure (2)
- Time-motion analysis (2)
- Time-resolved spectroscopy (2)
- Tiredness (2)
- To learners in which of the following categories does your work apply (2)
- Toll and Imd pathways (2)
- Tomato (2)
- Tomographie (2)
- Tonian–Cryogenian (2)
- Topik (2)
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- Total organic carbon (2)
- Totes Meer Störungssystem (2)
- Toxicokinetics (2)
- Trace element geochemistry (2)
- Training volume (2)
- Trans-European Suture Zone (2)
- Transcriptional memory (2)
- Transcriptome assembly (2)
- Transcriptomics (2)
- Transform faults (2)
- Transhimalaya (2)
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- Turkish German (2)
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- Typicality (2)
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- U-shaped curve (2)
- UK (2)
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- Usage (2)
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- acids (2)
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- aged (2)
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- breathing (2)
- breeding (2)
- bridge (2)
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- bromeliad (2)
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- browser platforms (2)
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- bulk heterojunctions (2)
- bullying victimization (2)
- bumps (2)
- bush encroachment (2)
- business incubators (2)
- business interruption (2)
- business model innovation (2)
- business process (2)
- business process modeling (2)
- business services (2)
- butyrylcholinesterase (2)
- buy recommendations (2)
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- cGMP (2)
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- callous-unemotional traits (2)
- callousness (2)
- cambridge cb4 0wf (2)
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- camelid antibody (2)
- camelid heavy-chain-only antibodies (2)
- canalization (2)
- cancer chemoprevention (2)
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- canoe racing (2)
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- canopy height (2)
- capabilities (2)
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- chains (2)
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- challenges (2)
- change of direction speed (2)
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- chaotic neural dynamics (2)
- chaperone (2)
- chaperones (2)
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- circulation of knowledge (2)
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- coast (2)
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- coherent noise (2)
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- comparative (2)
- comparative subclause (2)
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- comparison of devices (2)
- competencies (2)
- competition–defense trade‐off (2)
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- complex network (2)
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- concentration (2)
- concurrent checking (2)
Institut
- Institut für Physik und Astronomie (4839)
- Institut für Biochemie und Biologie (4656)
- Institut für Geowissenschaften (3280)
- Institut für Chemie (2844)
- Institut für Mathematik (1560)
- Department Psychologie (1394)
- Institut für Ernährungswissenschaft (1013)
- Department Linguistik (915)
- Wirtschaftswissenschaften (826)
- Institut für Informatik und Computational Science (793)
This review discusses picosecond ultrasonics experiments using ultrashort hard x-ray probe pulses to extract the transient strain response of laser-excited nanoscopic structures from Bragg-peak shifts. This method provides direct, layer-specific, and quantitative information on the picosecond strain response for structures down to few-nm thickness. We model the transient strain using the elastic wave equation and express the driving stress using Gruneisen parameters stating that the laser-induced stress is proportional to energy density changes in the microscopic subsystems of the solid, i.e., electrons, phonons and spins. The laser-driven strain response can thus serve as an ultrafast proxy for local energy-density and temperature changes, but we emphasize the importance of the nanoscale morphology for an accurate interpretation due to the Poisson effect. The presented experimental use cases encompass ultrathin and opaque metal-heterostructures, continuous and granular nanolayers as well as negative thermal expansion materials, that each pose a challenge to established all-optical techniques.
The Gutenberg-Richter (GR) and the Omori-Utsu (OU) law describe the earthquakes' energy release and temporal clustering and are thus of great importance for seismic hazard assessment. Motivated by experimental results, which indicate stress-dependent parameters, we consider a combined global data set of 127 main shock-aftershock sequences and perform a systematic study of the relationship between main shock-induced stress changes and associated seismicity patterns. For this purpose, we calculate space-dependent Coulomb Stress (& UDelta;CFS) and alternative receiver-independent stress metrics in the surrounding of the main shocks. Our results indicate a clear positive correlation between the GR b-value and the induced stress, contrasting expectations from laboratory experiments and suggesting a crucial role of structural heterogeneity and strength variations. Furthermore, we demonstrate that the aftershock productivity increases nonlinearly with stress, while the OU parameters c and p systematically decrease for increasing stress changes. Our partly unexpected findings can have an important impact on future estimations of the aftershock hazard.
Physical fitness of primary school children differs depending on their timing of school enrollment
(2023)
Previous research has shown that children who were enrolled to school according to the legal key date (i.e., keyage children, between eight and nine years in third grade) exhibited a linear physical fitness development in the ninth year of life. In contrast, children who were enrolled with a delay (i.e., older-than-keyage children [OTK], between nine and ten years in third grade) exhibited a lower physical fitness compared to what would be expected for their age. In these studies, cross-sectional age differences within third grade and timing of school enrollment were confounded. The present study investigated the longitudinal development of keyage and OTK children from third to fifth grade. This design also afforded a comparison of the two groups at the same average chronological age, that is a dissociation of the effects of timing of school enrollment and age. We tested six physical fitness components: cardiorespiratory endurance, coordination, speed, power of lower and upper limbs, and static balance. 1502 children (i.e., 1206 keyage and 296 OTK children) from 35 schools were tested in third, fourth, and fifth grade. Except for cardiorespiratory endurance, both groups developed from third to fourth and from fourth to fifth grade and keyage children outperformed OTK children at the average ages of 9.5 or 10.5 years. For cardiorespiratory endurance, there was no significant gain from fourth to fifth grade and keyage and OTK children did not differ significantly at 10.5 years of age. One reason for a delayed school enrollment could be that a child is (or is perceived as) biologically younger than their chronological age at the school entry examination, implying a negative correlation between chronological and biological age for OTK children. Indeed, a simple reflection of chronological age brought the developmental rate of the chronologically youngest OTK children in line with the developmental rate observed for keyage children, but did not eliminate all differences. The mapping of chronological and biological age of OTK children and other possible reasons for lower physical fitness of OTK children remain a task for future research.
The NGC 346 young stellar system and associated N66 giant H ii region in the Small Magellanic Cloud are the nearest example of a massive star-forming event in a low metallicity (Z approximate to 0.2Z (circle dot)) galaxy. With an age of less than or similar to 3 Myr this system provides a unique opportunity to study relationships between massive stars and their associated H ii region. Using archival data, we derive a total H alpha luminosity of L(H alpha) = 4.1 x 10(38) erg s(-1) corresponding to an H-photoionization rate of 3 x 10(50) s(-1). A comparison with a predicted stellar ionization rate derived from the more than 50 known O-stars in NGC 346, including massive stars recently classified from Hubble Space Telescope far-ultraviolet (FUV) spectra, indicates an approximate ionization balance. Spectra obtained with SALT suggest the ionization structure of N66 could be consistent with some leakage of ionizing photons. Due to the low metallicity, the FUV luminosity from NGC 346 is not confined to the interstellar cloud associated with N66. Ionization extends through much of the spatial extent of the N66 cloud complex, and most of the cloud mass is not ionized. The stellar mass estimated from nebular L(H alpha) appears to be lower than masses derived from the census of resolved stars which may indicate a disconnect between the formation of high and low mass stars in this region. We briefly discuss implications of the properties of N66 for studies of star formation and stellar feedback in low metallicity environments.
The unmixed debris of Gaia-Sausage/Enceladus in the form of a pair of halo stellar overdensities
(2022)
In the first billion years after its formation, the galaxy underwent several mergers with dwarf satellites of various masses. The debris of Gaia-Sausage/Enceladus (GSE), the galaxy responsible for the last significant merger of the Milky Way, dominates the inner halo and has been suggested to be the progenitor of both the Hercules-Aquila Cloud (HAC) and Virgo Overdensity (VOD). We combine SEGUE, APOGEE, Gaia, and StarHorse distances to characterize the chemodynamical properties and verify the link between HAC, VOD, and GSE. We find that the orbital eccentricity distributions of the stellar overdensities and GSE are comparable. We also find that they have similar, strongly peaked, metallicity distribution functions, reinforcing the hypothesis of common origin. Furthermore, we show that HAC and VOD are indistinguishable from the prototypical GSE population within all chemical-abundance spaces analyzed. All these evidences combined provide a clear demonstration that the GSE merger is the main progenitor of the stellar populations found within these halo overdensities.
All plant cells are encased in primary cell walls that determine plant morphology, but also protect the cells against the environment. Certain cells also produce a secondary wall that supports mechanically demanding processes, such as maintaining plant body stature and water transport inside plants. Both these walls are primarily composed of polysaccharides that are arranged in certain patterns to support cell functions. A key requisite for patterned cell walls is the arrangement of cortical microtubules that may direct the delivery of wall polymers and/or cell wall producing enzymes to certain plasma membrane locations. Microtubules also steer the synthesis of cellulose-the load-bearing structure in cell walls-at the plasma membrane. The organization and behaviour of the microtubule array are thus of fundamental importance to cell wall patterns. These aspects are controlled by the coordinated effort of small GTPases that probably coordinate a Turing's reaction-diffusion mechanism to drive microtubule patterns. Here, we give an overview on how wall patterns form in the water-transporting xylem vessels of plants. We discuss systems that have been used to dissect mechanisms that underpin the xylem wall patterns, emphasizing the VND6 and VND7 inducible systems, and outline challenges that lay ahead in this field.
Outcome-dependent effects of walking speed and age on quantitative and qualitative gait measures
(2022)
Background: Walking speed predicts many clinical outcomes in old age. However, a comprehensive assessment of how walking speed affects accelerometer based quantitative and qualitative gait measures in younger and older adults is lacking. Research question: What is the relationship between walking speed and quantitative and qualitative gait outcomes in younger and older adults? Methods: Younger (n = 27, age: 21.6) and older participants (n = 27, age: 69.5) completed 340 steps on a treadmill at speeds of 0.70 to a maximum of 1.75 m.s(-1). We used generalized additive mixed models to determine the relationship between walking speed and quantitative (stride length, stride time, stride frequency and their variability) and qualitative (stride regularity, stability, smoothness, symmetry, synchronization, predictability) gait measures extracted from trunk accelerations. Results: The type of relationship between walking speed and the majority of gait measures (quantitative and qualitative) was characterized as logarithmic, with more prominent speed-effects at speeds below 1.20 m.s(-1). Changes in quantitative measures included shorter strides, longer stride times, and a lower stride frequency, with more variability at lower speeds independent of age. For qualitative measures, we found a decrease in gait symmetry, stability and regularity in all directions with decreasing speeds, a decrease in gait predictability (Vertical, V, anterior-posterior, AP) and stronger gait synchronization (AP-mediolateral, ML, AP-V), and direction dependent effects of gait smoothness, which decreased in V direction, but increased in AP and ML directions with decreasing speeds. We found outcome-dependent effects of age on the quantitative and qualitative gait measures, with either no differences between age-groups, age-related differences that existed regardless of speed, and age-related differences in the type of relationship with walking speed. Significance: The relationship between walking speed and quantitative and qualitative gait measures, and the effects of age on this relationship, depends on the type of gait measure studied.
Efficient Removal of Tetracycline and Bisphenol A from Water with a New Hybrid Clay/TiO2 Composite
(2023)
New TiO2 hybrid composites were prepared fromkaolinclay, predried and carbonized biomass, and titanium tetraisopropoxideand explored for tetracycline (TET) and bisphenol A (BPA) removalfrom water. Overall, the removal rate is 84% for TET and 51% for BPA.The maximum adsorption capacities (q (m))are 30 and 23 mg/g for TET and BPA, respectively. These capacitiesare far greater than those obtained for unmodified TiO2. Increasing the ionic strength of the solution does not change theadsorption capacity of the adsorbent. pH changes only slightly changeBPA adsorption, while a pH > 7 significantly reduces the adsorptionof TET on the material. The Brouers-Sotolongo fractal modelbest describes the kinetic data for both TET and BPA adsorption, predictingthat the adsorption process occurs via a complex mechanism involvingvarious forces of attraction. Temkin and Freundlich isotherms, whichbest fit the equilibrium adsorption data for TET and BPA, respectively,suggest that adsorption sites are heterogeneous in nature. Overall,the composite materials are much more effective for TET removal fromaqueous solution than for BPA. This phenomenon is assigned to a differencein the TET/adsorbent interactions vs the BPA/adsorbent interactions:the decisive factor appears to be favorable electrostatic interactionsfor TET yielding a more effective TET removal.
The active global SARS-CoV-2 pandemic caused more than 426 million cases and 5.8 million deaths worldwide. The development of completely new drugs for such a novel disease is a challenging, time intensive process. Despite researchers around the world working on this task, no effective treatments have been developed yet. This emphasizes the importance of drug repurposing, where treatments are found among existing drugs that are meant for different diseases. A common approach to this is based on knowledge graphs, that condense relationships between entities like drugs, diseases and genes. Graph neural networks (GNNs) can then be used for the task at hand by predicting links in such knowledge graphs. Expanding on state-of-the-art GNN research, Doshi et al. recently developed the Dr-COVID model. We further extend their work using additional output interpretation strategies. The best aggregation strategy derives a top-100 ranking of 8,070 candidate drugs, 32 of which are currently being tested in COVID-19-related clinical trials. Moreover, we present an alternative application for the model, the generation of additional candidates based on a given pre-selection of drug candidates using collaborative filtering. In addition, we improved the implementation of the Dr-COVID model by significantly shortening the inference and pre-processing time by exploiting data-parallelism. As drug repurposing is a task that requires high computation and memory resources, we further accelerate the post-processing phase using a new emerging hardware-we propose a new approach to leverage the use of high-capacity Non-Volatile Memory for aggregate drug ranking.
Understanding the origin of inefficient photocurrent generation in organic solar cells with low energy offset remains key to realizing high-performance donor-acceptor systems. Here, we probe the origin of field-dependent free-charge generation and photoluminescence in wnon-fullereneacceptor (NFA)-based organic solar cells using the polymer PM6 and the NFA Y5-a non-halogenated sibling to Y6, with a smaller energetic offset to PM6. By performing time-delayed collection field (TDCF) measurements on a variety of samples with different electron transport layers and active layer thickness, we show that the fill factor and photocurrent are limited by field-dependent free charge generation in the bulk of the blend. We also introduce a new method of TDCF called m-TDCF to prove the absence of artifacts from non-geminate recombination of photogenerated and dark charge carriers near the electrodes. We then correlate free charge generation with steady-state photoluminescence intensity and find perfect anticorrelation between these two properties. Through this, we conclude that photocurrent generation in this low-offset system is entirely controlled by the field-dependent dissociation of local excitons into charge-transfer states. (c) 2023 Author(s).
Ore precipitation in porphyry copper systems is generally characterized by metal zoning (Cu-Mo to Zn-Pb-Ag), which is suggested to be variably related to solubility decreases during fluid cooling, fluid-rock interactions, partitioning during fluid phase separation and mixing with external fluids. Here, we present new advances of a numerical process model by considering published constraints on the temperature- and salinity-dependent solubility of Cu, Pb and Zn in the ore fluid. We quantitatively investigate the roles of vapor-brine separation, halite saturation, initial metal contents, fluid mixing and remobilization as first-order controls of the physical hydrology on ore formation. The results show that the magmatic vapor and brine phases ascend with different residence times but as miscible fluid mixtures, with salinity increases generating metal-undersaturated bulk fluids. The release rates of magmatic fluids affect the location of the thermohaline fronts, leading to contrasting mechanisms for ore precipitation: higher rates result in halite saturation without significant metal zoning, lower rates produce zoned ore shells due to mixing with meteoric water. Varying metal contents can affect the order of the final metal precipitation sequence. Redissolution of precipitated metals results in zoned ore shell patterns in more peripheral locations and also decouples halite saturation from ore precipitation.
We present a Reduced Order Model (ROM) which exploits recent developments in Physics Informed Neural Networks (PINNs) for solving inverse problems for the Navier-Stokes equations (NSE). In the proposed approach, the presence of simulated data for the fluid dynamics fields is assumed. A POD-Galerkin ROM is then constructed by applying POD on the snapshots matrices of the fluid fields and performing a Galerkin projection of the NSE (or the modified equations in case of turbulence modeling) onto the POD reduced basis. A POD-Galerkin PINN ROM is then derived by introducing deep neural networks which approximate the reduced outputs with the input being time and/or parameters of the model. The neural networks incorporate the physical equations (the POD-Galerkin reduced equations) into their structure as part of the loss function. Using this approach, the reduced model is able to approximate unknown parameters such as physical constants or the boundary conditions. A demonstration of the applicability of the proposed ROM is illustrated by three cases which are the steady flow around a backward step, the flow around a circular cylinder and the unsteady turbulent flow around a surface mounted cubic obstacle.
The oil palm (Elaeis guineensis Jacq.) produces a large amount of oil from the fruit. However, increasing the oil production in this fruit is still challenging. A recent study has shown that starch metabolism is essential for oil synthesis in fruit-producing species. Therefore, the transcriptomic analysis by RNA-seq was performed to observe gene expression alteration related to starch metabolism genes throughout the maturity stages of oil palm fruit with different oil yields. Gene expression profiles were examined with three different oil yields group (low, medium, and high) at six fruit development phases (4, 8, 12, 16, 20, and 22 weeks after pollination). We successfully identified and analyzed differentially expressed genes in oil palm mesocarps during development. The results showed that the transcriptome profile for each developmental phase was unique. Sucrose flux to the mesocarp tissue, rapid starch turnover, and high glycolytic activity have been identified as critical factors for oil production in oil palms. For starch metabolism and the glycolytic pathway, we identified specific gene expressions of enzyme isoforms (isozymes) that correlated with oil production, which may determine the oil content. This study provides valuable information for creating new high-oil-yielding palm varieties via breeding programs or genome editing approaches.
Background
Self-regulation (SR) as the ability to regulate one's own physical state, emotions, cognitions, and behavior, is considered to play a pivotal role in the concurrent and subsequent mental and physical health of an individual. Although SR skills encompass numerous sub-facets, previous research has often focused on only one or a few of these sub-facets, and only rarely on adolescence. Therefore, little is known about the development of the sub-facets, their interplay, and their specific contributions to future developmental outcomes, particularly in adolescence. To fill these research gaps, this study aims to prospectively examine (1) the development of SR and (2) their influence on adolescent-specific developmental outcomes in a large community sample.
Methods/design
Based on previously collected data from the Potsdam Intrapersonal Developmental Risk (PIER) study with three measurement points, the present prospective, longitudinal study aims to add a fourth measurement point (PIERYOUTH). We aim to retain at least 1074 participants now between 16 and 23 years of the initially 1657 participants (6-11 years of age at the first measurement point in 2012/2013; 52.2% female). The study will continue to follow a multi-method (questionnaires, physiological assessments, performance-based computer tasks), multi-facet (assessing various domains of SR), and multi-rater (self-, parent-, and teacher-report) approach. In addition, a broad range of adolescent-specific developmental outcomes is considered. In doing so, we will cover the development of SR and relevant outcomes over the period of 10 years. In addition, we intend to conduct a fifth measurement point (given prolonged funding) to investigate development up to young adulthood.
Discussion
With its broad and multimethodological approach, PIERYOUTH aims to contribute to a deeper understanding of the development and role of various SR sub-facets from middle childhood to adolescence. The large sample size and low drop-out rates in the first three measurements points form a sound database for our present prospective research.Trial registration German Clinical Trials Register, registration number DRKS00030847.
Keeping cool on hot days
(2023)
Long-lived organisms are likely to respond to a rapidly changing climate with behavioral flexibility. Animals inhabiting the arid parts of southern Africa face a particularly rapid rise in temperature which in combination with food and water scarcity places substantial constraints on the ability of animals to tolerate heat. We investigated how three species of African antelope-springbok Antidorcas marsupialis, kudu Tragelaphus strepsiceros and eland T. oryx-differing in body size, habitat preference and movement ecology, change their activity in response to extreme heat in an arid savanna. Serving as a proxy for activity, dynamic body acceleration data recorded every five minutes were analyzed for seven to eight individuals per species for the three hottest months of the year. Activity responses to heat during the hottest time of day (the afternoons) were investigated and diel activity patterns were compared between hot and cool days. Springbok, which prefer open habitat, are highly mobile and the smallest of the species studied, showed the greatest decrease in activity with rising temperature. Furthermore, springbok showed reduced mean activity over the 24 h cycle on hot days compared to cool days. Large-bodied eland seemed less affected by afternoon heat than springbok. While eland also reduced diurnal activity on hot days compared to cool days, they compensated for this by increasing nocturnal activity, possibly because their predation risk is lower. Kudu, which are comparatively sedentary and typically occupy shady habitat, seemed least affected during the hottest time of day and showed no appreciable difference in diel activity patterns between hot and cool days. The interplay between habitat preference, body size, movement patterns, and other factors seems complex and even sub-lethal levels of heat stress have been shown to impact an animal's long-term survival and reproduction. Thus, differing heat tolerances among species could result in a shift in the composition of African herbivore communities as temperatures continue to rise, with significant implications for economically important wildlife-based land use and conservation.
Starch has been a convenient, economically important polymer with substantial applications in the food and processing industry. However, native starches present restricted applications, which hinder their industrial usage. Therefore, modification of starch is carried out to augment the positive characteristics and eliminate the limitations of the native starches. Modifications of starch can result in generating novel polymers with numerous functional and value-added properties that suit the needs of the industry. Here, we summarize the possible starch modifications in planta and outside the plant system (physical, chemical, and enzymatic) and their corresponding applications. In addition, this review will highlight the implications of each starch property adjustment.
Students enter school with a vast range of individual differences, resulting from the complex interplay between genetic dispositions and unequal environmental conditions. Schools thus face the challenge of organizing instruction and providing equal opportunities for students with diverse needs. Schools have traditionally managed student heterogeneity by sorting students both within and between schools according to their academic ability. However, empirical evidence suggests that such tracking approaches increase inequalities. In more recent years, driven largely by technological advances, there have been calls to embrace students' individual differences in the classroom and to personalize students' learning experiences. A central justification for personalized learning is its potential to improve educational equity. In this paper, we discuss whether and under which conditions personalized learning can indeed increase equity in K-12 education by bringing together empirical and theoretical insights from different fields, including the learning sciences, philosophy, psychology, and sociology. We distinguish between different conceptions of equity and argue that personalized learning is unlikely to result in "equality of outcomes" and, by definition, does not provide "equality of inputs". However, if implemented in a high-quality way, personalized learning is in line with "adequacy" notions of equity, which aim to equip all students with the basic competencies to participate in society as active members and to live meaningful lives.
Knowledge on the response of sediment export to recent climate change in glacierized areas in the European Alps is limited, primarily because long-term records of suspended sediment concentrations (SSCs) are scarce. Here we tested the estimation of sediment export of the past five decades using quantile regression forest (QRF), a nonparametric, multivariate regression based on random forest. The regression builds on short-term records of SSCs and long records of the most important hydroclimatic drivers (discharge, precipitation and air temperature - QPT). We trained independent models for two nested and partially glacier-covered catchments, Vent (98 km(2)) and Vernagt (11.4 km(2)), in the upper otztal in Tyrol, Austria (1891 to 3772 m a.s.l.), where available QPT records start in 1967 and 1975. To assess temporal extrapolation ability, we used two 2-year SSC datasets at gauge Vernagt, which are almost 20 years apart, for a validation. For Vent, we performed a five-fold cross-validation on the 15 years of SSC measurements. Further, we quantified the number of days where predictors exceeded the range represented in the training dataset, as the inability to extrapolate beyond this range is a known limitation of QRF. Finally, we compared QRF performance to sediment rating curves (SRCs). We analyzed the modeled sediment export time series, the predictors and glacier mass balance data for trends (Mann-Kendall test and Sen's slope estimator) and step-like changes (using the widely applied Pettitt test and a complementary Bayesian approach).Our validation at gauge Vernagt demonstrated that QRF performs well in estimating past daily sediment export (Nash-Sutcliffe efficiency (NSE) of 0.73) and satisfactorily for SSCs (NSE of 0.51), despite the small training dataset. The temporal extrapolation ability of QRF was superior to SRCs, especially in periods with high-SSC events, which demonstrated the ability of QRF to model threshold effects. Days with high SSCs tended to be underestimated, but the effect on annual yields was small. Days with predictor exceedances were rare, indicating a good representativity of the training dataset. Finally, the QRF reconstruction models outperformed SRCs by about 20 percent points of the explained variance.Significant positive trends in the reconstructed annual suspended sediment yields were found at both gauges, with distinct step-like increases around 1981. This was linked to increased glacier melt, which became apparent through step-like increases in discharge at both gauges as well as change points in mass balances of the two largest glaciers in the Vent catchment. We identified exceptionally high July temperatures in 1982 and 1983 as a likely cause. In contrast, we did not find coinciding change points in precipitation. Opposing trends at the two gauges after 1981 suggest different timings of "peak sediment". We conclude that, given large-enough training datasets, the presented QRF approach is a promising tool with the ability to deepen our understanding of the response of high-alpine areas to decadal climate change.
Background:
Contamination detection is a important step that should be carefully considered in early stages when designing and performing microbiome studies to avoid biased outcomes. Detecting and removing true contaminants is challenging, especially in low-biomass samples or in studies lacking proper controls. Interactive visualizations and analysis platforms are crucial to better guide this step, to help to identify and detect noisy patterns that could potentially be contamination. Additionally, external evidence, like aggregation of several contamination detection methods and the use of common contaminants reported in the literature, could help to discover and mitigate contamination.
Results:
We propose GRIMER, a tool that performs automated analyses and generates a portable and interactive dashboard integrating annotation, taxonomy, and metadata. It unifies several sources of evidence to help detect contamination. GRIMER is independent of quantification methods and directly analyzes contingency tables to create an interactive and offline report. Reports can be created in seconds and are accessible for nonspecialists, providing an intuitive set of charts to explore data distribution among observations and samples and its connections with external sources. Further, we compiled and used an extensive list of possible external contaminant taxa and common contaminants with 210 genera and 627 species reported in 22 published articles.
Conclusion:
GRIMER enables visual data exploration and analysis, supporting contamination detection in microbiome studies. The tool and data presented are open source and available at https://gitlab.com/dacs-hpi/grimer.
Background
The aggregation of a series of N-of-1 trials presents an innovative and efficient study design, as an alternative to traditional randomized clinical trials. Challenges for the statistical analysis arise when there is carry-over or complex dependencies of the treatment effect of interest.
Methods
In this study, we evaluate and compare methods for the analysis of aggregated N-of-1 trials in different scenarios with carry-over and complex dependencies of treatment effects on covariates. For this, we simulate data of a series of N-of-1 trials for Chronic Nonspecific Low Back Pain based on assumed causal relationships parameterized by directed acyclic graphs. In addition to existing statistical methods such as regression models, Bayesian Networks, and G-estimation, we introduce a carry-over adjusted parametric model (COAPM).
Results
The results show that all evaluated existing models have a good performance when there is no carry-over and no treatment dependence. When there is carry-over, COAPM yields unbiased and more efficient estimates while all other methods show some bias in the estimation. When there is known treatment dependence, all approaches that are capable to model it yield unbiased estimates. Finally, the efficiency of all methods decreases slightly when there are missing values, and the bias in the estimates can also increase.
Conclusions
This study presents a systematic evaluation of existing and novel approaches for the statistical analysis of a series of N-of-1 trials. We derive practical recommendations which methods may be best in which scenarios.
Jewish Studies and Postcolonial Studies are often thought to be at odds. Both disciplines intensively debate modernity, troubling its universalist claims and showing the contradictory nature of its promises. The call to provincialize Europe allows scholars from both disciplines to think, articulate and represent modern experiences beyond Europe and engage critically with traditions of modernity across disciplines, temporalities and geographies. Mapping Sephardi and other minor perspectives on modernity from across the globe in this volume, we are presenting fascinating cases and exploring new terrain where a fruitful encounter between Jewish and Postcolonial Studies can happen.
Graphene is well-knownfor its unique combination of electricaland mechanical properties. However, its vanishing band gap limitsthe use of graphene in microelectronics. Covalent functionalizationof graphene has been a common approach to address this critical issueand introduce a band gap. In this Article, we systematically analyzethe functionalization of single-layer graphene (SLG) and bilayer graphene(BLG) with methyl (CH3) using periodic density functionaltheory (DFT) at the PBE+D3 level of theory. We also include a comparisonof methylated single-layer and bilayer graphene, as well as a discussionof different methylation options (radicalic, cationic, and anionic).For SLG, methyl coverages ranging from 1/8 to 1/1, (i.e.,the fully methylated analogue of graphane) are considered. We findthat up to a coverage theta of 1/2, graphene readily accepts CH3, with neighbor CH3 groups preferring trans positions. Above theta = 1/2, the tendency to accept further CH3 weakens and the lattice constant increases. The band gapbehaves less regularly, but overall it increases with increasing methylcoverage. Thus, methylated graphene shows potential for developingband gap-tuned microelectronics devices and may offer further functionalizationoptions. To guide in the interpretation of methylation experiments,vibrational signatures of various species are characterized by normal-modeanalysis (NMA), their vibrational density of states (VDOS), and infrared(IR) spectra, the latter two are obtained from ab initio moleculardynamics (AIMD) in combination with a velocity-velocity autocorrelationfunction (VVAF) approach.
Genomic and epigenomic determinants of heat stress-induced transcriptional memory in Arabidopsis
(2023)
Background
Transcriptional regulation is a key aspect of environmental stress responses. Heat stress induces transcriptional memory, i.e., sustained induction or enhanced re-induction of transcription, that allows plants to respond more efficiently to a recurrent HS. In light of more frequent temperature extremes due to climate change, improving heat tolerance in crop plants is an important breeding goal. However, not all heat stress-inducible genes show transcriptional memory, and it is unclear what distinguishes memory from non-memory genes. To address this issue and understand the genome and epigenome architecture of transcriptional memory after heat stress, we identify the global target genes of two key memory heat shock transcription factors, HSFA2 and HSFA3, using time course ChIP-seq.
Results
HSFA2 and HSFA3 show near identical binding patterns. In vitro and in vivo binding strength is highly correlated, indicating the importance of DNA sequence elements. In particular, genes with transcriptional memory are strongly enriched for a tripartite heat shock element, and are hallmarked by several features: low expression levels in the absence of heat stress, accessible chromatin environment, and heat stress-induced enrichment of H3K4 trimethylation. These results are confirmed by an orthogonal transcriptomic data set using both de novo clustering and an established definition of memory genes.
Conclusions
Our findings provide an integrated view of HSF-dependent transcriptional memory and shed light on its sequence and chromatin determinants, enabling the prediction and engineering of genes with transcriptional memory behavior.
Rankings have grown in importance in the last decades. This is particularly evident in, but not limited to, academia. In this paper, we propose a power analytical take on academic rankings as a transnational(izing) phenomenon. In doing so, we make two contributions. First, we develop a conceptual definition of rankings as consecratory institutions. After providing an overview of the most prominent types of rankings in the academic field and discussing the different forms they can take, we suggest that rankings operate through subjectivation, zero-sum comparisons, quantification, publication and generating a doxical belief. Second, we propose that rankings fulfil a strategic double function. As a particularly momentous consecratory institution, rankings propel power shifts in the academic field and beyond by preferring (and being pushed by) specific academic milieus, types of agents, paradigms, and strategies. As a dispositif, rankings operate at the intersection of different fields, open academic fields up for a lay audience and advance processes of transnationalization by facilitating new modes of governance for hubs of state institutions, private corporations, media corporations, and data providers. Concluding, we argue that the consecration and dispositif functions rely on some basic principles of the practical functioning of rankings.
Economic evaluation of digital therapeutic care apps for unsupervised treatment of low back pain
(2023)
Background:
Digital therapeutic care (DTC) programs are unsupervised app-based treatments that provide video exercises and educational material to patients with nonspecific low back pain during episodes of pain and functional disability. German statutory health insurance can reimburse DTC programs since 2019, but evidence on efficacy and reasonable pricing remains scarce. This paper presents a probabilistic sensitivity analysis (PSA) to evaluate the efficacy and cost-utility of a DTC app against treatment as usual (TAU) in Germany.
Objective:
The aim of this study was to perform a PSA in the form of a Monte Carlo simulation based on the deterministic base case analysis to account for model assumptions and parameter uncertainty. We also intend to explore to what extent the results in this probabilistic analysis differ from the results in the base case analysis and to what extent a shortage of outcome data concerning quality-of-life (QoL) metrics impacts the overall results.
Methods:
The PSA builds upon a state-transition Markov chain with a 4-week cycle length over a model time horizon of 3 years from a recently published deterministic cost-utility analysis. A Monte Carlo simulation with 10,000 iterations and a cohort size of 10,000 was employed to evaluate the cost-utility from a societal perspective. Quality-adjusted life years (QALYs) were derived from Veterans RAND 6-Dimension (VR-6D) and Short-Form 6-Dimension (SF-6D) single utility scores. Finally, we also simulated reducing the price for a 3-month app prescription to analyze at which price threshold DTC would result in being the dominant strategy over TAU in Germany.
Results:
The Monte Carlo simulation yielded on average a euro135.97 (a currency exchange rate of EUR euro1=US $1.069 is applicable) incremental cost and 0.004 incremental QALYs per person and year for the unsupervised DTC app strategy compared to in-person physiotherapy in Germany. The corresponding incremental cost-utility ratio (ICUR) amounts to an additional euro34,315.19 per additional QALY. DTC yielded more QALYs in 54.96% of the iterations. DTC dominates TAU in 24.04% of the iterations for QALYs. Reducing the app price in the simulation from currently euro239.96 to euro164.61 for a 3-month prescription could yield a negative ICUR and thus make DTC the dominant strategy, even though the estimated probability of DTC being more effective than TAU is only 54.96%.
Conclusions:
Decision-makers should be cautious when considering the reimbursement of DTC apps since no significant treatment effect was found, and the probability of cost-effectiveness remains below 60% even for an infinite willingness-to-pay threshold. More app-based studies involving the utilization of QoL outcome parameters are urgently needed to account for the low and limited precision of the available QoL input parameters, which are crucial to making profound recommendations concerning the cost-utility of novel apps.
In this programmatic introduction, we lay out the foundations of an approach to analyzing knowledge-based political phenomena beyond the nation state from a field perspective. We understand transnational field analysis as a research program comprising genuine theoretical and methodological assumptions. While extant research is well aware of the theoretical assumptions of transnational field analysis, there is thus far relatively little awareness of the importance of its methodological premises. Addressing this imbalanced picture, we identify five methodological principles and specify consequences for studies of transnational fields. Our approach emphasizes that performing transnational field analysis goes beyond “taking a theory to the field”; it means engaging in and reflecting upon a complex research process that simultaneously draws upon and constructs theories of fields.
Reliability of the active knee joint position sense test and influence of limb dominance and sex
(2023)
The output of a sensorimotor performance can be measured with the joint position sense (JPS) test. However, investigations of leg dominance, sex and quality measures on this test are limited. Therefore, these potential influencing factors as well as reliability and consistency measures were evaluated for angular reproduction performance and neuromuscular activity during the active knee JPS test in healthy participants. Twenty healthy participants (10 males; 10 females; age 29 +/- 8 years; height 165 +/- 39 cm; body mass 69 +/- 13 kg) performed a seated knee JPS test with a target angle of 50 degrees. Measurements were conducted in two sessions separated by two weeks and consisted of two blocks of continuous angular reproduction (three minutes each block). The difference between reproduced and target angle was identified as angular error measured by an electrogoniometer. During reproduction, the neuromuscular activity of the quadriceps muscle was assessed by surface electromyography. Neuromuscular activity was normalized to submaximal voluntary contraction (subMVC) and displayed per muscle and movement phase. Differences between leg dominance and sex were calculated using Friedman-test (alpha = 0.05). Reliability measures including intraclass correlation coefficient (ICC), Bland-Altman analysis (bias +/- limits of agreement (LoA)) and minimal detectable change (MDC) were analysed. No significant differences between leg dominance and sex were found in angular error and neuromuscular activity. Angular error demonstrated inter-session ICC scores of 0.424 with a bias of 2.4 degrees (+/- 2.4 degrees LoA) as well as MDC of 6.8 degrees and moderate intra-session ICC (0.723) with a bias of 1.4 degrees (+/- 1.65 degrees LoA) as well as MDC of 4.7 degrees. Neuromuscular activity for all muscles and movement phases illustrated inter-session ICC ranging from 0.432 to 0.809 with biases between - 2.5 and 13.6% subMVC and MDC from 13.4 to 63.9% subMVC. Intra-session ICC ranged from 0.705 to 0.987 with biases of - 7.7 to 2.4% subMVC and MDC of 2.7 to 46.5% subMVC. Leg dominance and sex seem not to influence angular reproduction performance and neuromuscular activity. Poor to excellent relative reliability paired with an acceptable consistency confirm findings of previous studies. Comparisons to pathological populations should be conducted with caution.
In the following pages I discuss how,and to what extent, the eminent Zionist thinker Max Nordau, himself of Sephardic ancestry, viewed the history of the Jews of the Iberian Peninsula in the context of his general critique of assimilation not only in regard to Jews,but in a more comprehensive understanding as well. My focus here is on the significance of assimilation in the history of the Jews on the Iberian Peninsula as reflected in Nordau’s writings, with an additional emphasis on his two visits to Spain, thefirst in 1875 and again between 1914 and 1920. In so doing, I attempt to integrate Ashkenazic and Sephardic history into one field of Jewish Studies. The relationship between the two has not yet been researched comprehensively, particularly in the context of the historical study of Zionism.
Carvajal and the Franciscans
(2022)
Luis de Carvajal the Younger (1567–1596) is without doubt one of the most famous victims of the Mexican Inquisition. In 1595, Luis and his family were found guilty of “Judaizing” and sentenced to death. Due to his autobiography and letters which survived in the dossiers of his trials, scholars have been able to trace important aspects of Carvajal’s life, his religious thought, and his self-fashioning as a Jewish martyr. However, one question that has not yet been entirely discussed is Carvajal’s messianism in the context of New World geographies and influences.
This chapter uses Carvajal’s autobiography, his letters, and his declarations during the trials to analyze the meaning of “the Americas” in Carvajal’s eschatological thought and to reflect upon possible influences from Mexican Franciscans and Christian millenarians with whom Carvajal was in contact between 1590 and 1595. It places Carvajal’s case in the broader context of recent studies of “converso messianism” and Jewish-Christian interactions in early modern eschatological and millenarian settings. It thus contributes to the exploration of entanglements between Jewish and Christian eschatological expectations in the early modern Atlantic World.
In Time and the Other Johannes Fabian analysed how modern conceptions of time were “not only secularized and naturalized but also thoroughly spatialized.” According to Fabian, this was particularly visible in modern anthropology which “promoted a scheme in terms of which not only past cultures but all living societies were irrevocably placed on a temporal slope, a stream of Time – some upstream, others downstream.”3 Anthropologists attributed otherness to a distant past which was traditionally associated with cultural retardation, i.e. a lower degree of development, progress, and civilization. Cultural difference was expressed in terms of temporal distance while temporal distance was attributed to spatial remoteness. The result was a phenomenon that Fabian coined “the denial of coevalness” which pointed towards “a persistent and systematic tendency to place the referent(s) of anthropology in a Time other than the present of the producer of anthropological discourse.
Nationalism was declared to be dead too early. A postnational age was announced, and liberalism claimed to have been victorious by the end of the Cold War. At the same time postnational order was proclaimed in which transnational alliances like the European Union were supposed to become more important in international relations. But we witnessed the rise a strong nationalism during the early 21st century instead, and right wing parties are able to gain more and more votes in elections that are often characterized by nationalist agendas. This volume shows how nationalist dreams and fears alike determine politics in an age that was supposed to witness a rather peaceful coexistence by those who consider transnational ideas more valuable than national demands. It will deal with different case studies to show why and how nationalism made its way back to the common consciousness and which elements stimulated the re-establishment of the aggressive nation state. The volume will therefore look at the continuities of empire, actual and imagined, the role of "foreign-" and "otherness" for nationalist narratives, and try to explain how globalization stimulated the rise of 21st century nationalisms as well.
This year’s edition of the Yearbook of the Selma Stern Center for Jewish Studies Berlin-Brandenburg (ZJS) highlights innovative approaches to the study of Sephardic history in colonial and postcolonial contexts beyond Europe. The authors intertwine the particularities of their case studies with reflections on patterns of belonging, memorial cultures, and a transnational network of connections spanning from early modern times to the twentieth century.
In the context of the early modern Atlantic world, two essays explore the notion of a Sephardic empire among Portuguese Jewish communities as well as transatlantic entanglements in and beyond the Danish Caribbean. In the frameworks of Spain as well as (post-)colonial Egypt and Morocco, three articles reflect on Jewish citizenship, modes of belonging, and present-day commemorative events of Jewish history across the Mediterranean and beyond.
These collected contributions are the outcome of activities at the ZJS dedicated to Sephardic Studies during the academic year 2020—21.
Religious Mapping Erbil (RME) is a joint project of teams from the Catholic University in Erbil (CUE), Salahaddin University-Erbil (SUE) and Tishk International University (TIU) under the guidance of the University of Potsdam (UP). From 2018 to 2022, the project was financed by the German Academic Exchange Service (DAAD).
This project involves scholars of various disciplines including religious studies, Islamic studies, English language, applied computing, and computer engineering. The research is a cooperation of students, PhD candidates and advanced scholars.
The project attempts to display the religious diversity in Erbil, the fast-changing capital of Iraqi Kurdistan. Unlike a census or a survey, which focuses on individuals, RME presents the locations (mosques, churches, synagogues, temples and other venues) together with the history and social profiles of the congregations meeting there. [insert tiny map or part of it]
The data were obtained by visiting the locations, observing their services, interviewing community leaders (mostly imams and priests), evaluating information from the Ministry of Endowment and Religious Affairs, and by consulting websites. All investigations followed the same pattern, consisting of (I) spatiotemporal and (III) social dimensions, framed by (II) religious performance.
Integrated Seismic Program (ISP) is a graphical user interface designed to facilitate and provide a user-friendly framework for performing diverse common and advanced tasks in seismological research. ISP is composed of five main modules for earthquake location, time-frequency analysis and advanced signal processing, implementation of array techniques to estimate the slowness vector, seismic moment tensor inversion, and receiver function computation and analysis. In addition, several support tools are available, allowing the user to create an event database, download data from International Federation of Digital Seismograph Networks services, inspect the background noise, and compute synthetic seismograms. ISP is written in Python3, supported by several open-source and/or publicly available tools. Its modular design allows for new features to be added in a collaborative development environment.
Quinoa (Chenopodium quinoa Willd.) is an herbaceous annual crop of the amaranth family (Amaranthaceae). It is increasingly cultivated for its nutritious grains, which are rich in protein and essential amino acids, lipids, and minerals. Quinoa exhibits a high tolerance towards various abiotic stresses including drought and salinity, which supports its agricultural cultivation under climate change conditions. The use of quinoa grains is compromised by anti-nutritional saponins, a terpenoid class of secondary metabolites deposited in the seed coat; their removal before consumption requires extensive washing, an economically and environmentally unfavorable process; or their accumulation can be reduced through breeding. In this study, we analyzed the seed metabolomes, including amino acids, fatty acids, and saponins, from 471 quinoa cultivars, including two related species, by liquid chromatography - mass spectrometry. Additionally, we determined a large number of agronomic traits including biomass, flowering time, and seed yield. The results revealed considerable diversity between genotypes and provide a knowledge base for future breeding or genome editing of quinoa.
Geometry, 11B, 13C chemical shifts and the spatial magnetic properties (Through-Space NMR Shieldings -TSNMRS) of both cations and anions of boron-trapped N-heterocyclic carbenes (NHCs) and cyclic (alkyl)(amino)carbenes (CAACs) and of the corresponding diborane/diborene/diboryne dis-carbene adducts have been calculated using the GIAO perturbation method employing the nucleus independent chemical shift (NICS) concept; the TSNMRS results are visualized as iso-chemical-shielding surfaces (ICSS) of various size and direction. The ICSS of the TSNMRS (actually the anisotropy effects measurable in 1H NMR spectroscopy) are employed to qualify and quantify the present multiple bond character of the Carbene-Boron bond in the trapped NHCs and CAACs. Results are confirmed by bond length and 11B/13C chemical shift variations. Thus the partial multiple bond character of the Carbene-Boron bond cannot be expressed by the arrow of weak, much longer dative bonds and should be omitted as in other covalent lone pair-it or triel bonds. & COPY; 2023 Elsevier Ltd. All rights reserved.
The heat is on
(2023)
Climate conditions severely impact the activity and, consequently, the fitness of wildlife species across the globe. Wildlife can respond to new climatic conditions, but the pace of human-induced change limits opportunities for adaptation or migration. Thus, how these changes affect behavior, movement patterns, and activity levels remains unclear. In this study, we investigate how extreme weather conditions affect the activity of European hares (Lepus europaeus) during their peak reproduction period. When hares must additionally invest energy in mating, prevailing against competitors, or lactating, we investigated their sensitivities to rising temperatures, wind speed, and humidity. To quantify their activity, we used the overall dynamic body acceleration (ODBA) calculated from tri-axial acceleration measurements of 33 GPS-collared hares. Our analysis revealed that temperature, humidity, and wind speed are important in explaining changes in activity, with a strong response for high temperatures above 25 & DEG;C and the highest change in activity during temperature extremes of over 35 & DEG;C during their inactive period. Further, we found a non-linear relationship between temperature and activity and an interaction of activity changes between day and night. Activity increased at higher temperatures during the inactive period (day) and decreased during the active period (night). This decrease was strongest during hot tropical nights. At a stage of life when mammals such as hares must substantially invest in reproduction, the sensitivity of females to extreme temperatures was particularly pronounced. Similarly, both sexes increased their activity at high humidity levels during the day and low wind speeds, irrespective of the time of day, while the effect of humidity was stronger for males. Our findings highlight the importance of understanding the complex relationships between extreme weather conditions and mammal behavior, critical for conservation and management. With ongoing climate change, extreme weather events such as heat waves and heavy rainfall are predicted to occur more often and last longer. These events will directly impact the fitness of hares and other wildlife species and hence the population dynamics of already declining populations across Europe.
Perception of peripersonal space (PPS) and interpersonal distance (IPD) has been shown to be modified by external factors such as perceived danger, the use of tools, and social factors. Especially in times of social distancing in the context of the COVID-19 pandemic, it is vital to study factors that modify PPS and IPD. The present work addresses the question of whether wearing a face mask as a protection tool and social interaction impact the perception of IPD. We tested estimated IPD in pictures at three distances: 50 cm, 90 cm, and 150 cm in both social interaction (shaking hands) and without interaction and when the two people in the pictures wore a face mask or not. Data from 60 subjects were analyzed in a linear mixed model (on both difference in distance estimation to the depicted distance and in absolute distance estimation) and in a 3 (distance: 50, 90, 150) x 2 (interaction: no interaction, shake hands), x 2 face mask (no mask, mask) rmANOVA on distance estimation difference. All analyses showed that at a distance of 50 and 90 cm, participants generally underestimated the IPD while at an IPD of 150 cm, participants overestimated the distance. This could be grounded in perceived danger and avoidance behavior at closer distances, while the wider distance between persons was not perceived as dangerous. Our findings at an IPD of 90 cm show that social interaction has the largest effect at the border of our PPS, while the face mask did not affect social interaction at either distance. In addition, the ANOVA results indicate that when no social interaction was displayed, participants felt less unsafe when depicted persons wore a face mask at distances of 90 and 150 cm. This shows that participants are on the one hand aware of the given safety measures and internalized them; on the other hand, that refraining from physical social interaction helps to get close to other persons.
Sensorimotor control can be impaired by slacked muscle spindles. This was shown for reflex responses and, recently, also for muscular stability in the sense of Adaptive Force (AF). The slack in muscle spindles was generated by contracting the lengthened muscle followed by passive shortening. AF was suggested to specifically reflect sensorimotor control since it requires tension-length control in adaptation to an increasing load. This study investigated AF parameters in reaction to another, manually performed slack procedure in a preselected sample (n = 13). The AF of 11 elbow and 12 hip flexors was assessed by an objectified manual muscle test (MMT) using a handheld device. Maximal isometric AF was significantly reduced after manual spindle technique vs. regular MMT. Muscle lengthening started at 64.93 & PLUSMN; 12.46% of maximal voluntary isometric contraction (MVIC). During regular MMT, muscle length could be maintained stable until 92.53 & PLUSMN; 10.12% of MVIC. Hence, muscular stability measured by AF was impaired after spindle manipulation. Force oscillations arose at a significantly lower level for regular vs. spindle. This supports the assumption that they are a prerequisite for stable adaptation. Reduced muscular stability in reaction to slack procedures is considered physiological since sensory information is misled. It is proposed to use slack procedures to test the functionality of the neuromuscular system, which is relevant for clinical practice.
Introduction
Balance is vital for human health and experiments have been conducted to measure the mechanisms of postural control, for example studying reflex responses to simulated perturbations. Such studies are frequent in walking but less common in running, and an understanding of reflex responses to trip-like disturbances could enhance our understanding of human gait and improve approaches to training and rehabilitation. Therefore, the primary aim of this study was to investigate the technical validity and reliability of a treadmill running protocol with perturbations. A further exploratory aim was to evaluate the associated neuromuscular reflex responses to the perturbations, in the lower limbs.
Methods
Twelve healthy participants completed a running protocol (9 km/h) test-retest (2 weeks apart), whereby 30 unilateral perturbations were executed via the treadmill belts (presets:2.0 m/s amplitude;150 ms delay (post-heel contact);100ms duration). Validity of the perturbations was assessed via mean +/- SD comparison, percentage error calculation between the preset and recorded perturbation characteristics (PE%), and coefficient of variation (CV%). Test-retest reliability (TRV%) and Bland-Altman analysis (BLA; bias +/- 1.96 * SD) was calculated for reliability. To measure reflex activity, electromyography (EMG) was applied in both legs. EMG amplitudes (root mean square normalized to unperturbed strides) and latencies [ms] were analysed descriptively.
Results
Left-side perturbation amplitude was 1.9 +/- 0.1 m/s, delay 105 +/- 2 ms, and duration 78 +/- 1 ms. Right-side perturbation amplitude was 1.9 +/- 0.1 m/s, delay 118 +/- 2 ms, duration 78 +/- 1 ms. PE% ranged from 5-30% for the recorded perturbations. CV% of the perturbations ranged from 19.5-76.8%. TRV% for the perturbations was 6.4-16.6%. BLA for the left was amplitude: 0.0 +/- 0.3m/s, delay: 0 +/- 17 ms, duration: 2 +/- 13 ms, and for the right was amplitude: 0.1 +/- 0.7, delay: 4 +/- 40 ms, duration: 1 +/- 35 ms. EMG amplitudes ranged from 175 +/- 141%-454 +/- 359% in both limbs. Latencies were 109 +/- 12-116 +/- 23 ms in the tibialis anterior, and 128 +/- 49-157 +/- 20 ms in the biceps femoris.
Discussion
Generally, this study indicated sufficient validity and reliability of the current setup considering the technical challenges and limitations, although the reliability of the right-sided perturbations could be questioned. The protocol provoked reflex responses in the lower extremities, especially in the leading leg. Acute neuromusculoskeletal adjustments to the perturbations could be studied and compared in clinical and healthy running populations, and the protocol could be utilised to monitor chronic adaptations to interventions over time.
High-solid-content polystyrene and polyvinyl acetate dispersions of polymer particles with a 50 nm to 500 nm mean particle diameter and 12-55% (w/w) solid content have been produced via emulsion polymerization and characterized regarding their optical and physical properties. Both systems have been analyzed with common particle-size-measuring techniques like dynamic light scattering (DLS) and static light scattering (SLS) and compared to inline particle size distribution (PSD) measurements via photon density wave (PDW) spectroscopy in undiluted samples. It is shown that particle size measurements of undiluted polystyrene dispersions are in good agreement between analysis methods. However, for polyvinyl acetate particles, size determination is challenging due to bound water in the produced polymer. For the first time, water-swelling factors were determined via an iterative approach of PDW spectroscopy error (X-2) minimization. It is shown that water-swollen particles can be analyzed in high-solid-content solutions and their physical properties can be assumed to determine the refractive index, density, and volume fraction in dispersion. It was found that assumed water swelling improved the reduced scattering coefficient fit by PDW spectroscopy by up to ten times and particle size determination was refined and enabled. Particle size analysis of the water-swollen particles agreed well with offline-based state-of-the-art techniques.
This study provides a synthesis of corpus-based and experimental investigations of word-order preferences in German infinitival complementation. We carried out a systematic analysis of present-day German corpora to establish frequency distributions of different word-order options: extraposition, intraposition, and 'third construction'. We then examined, firstly, whether and to what extent corpus frequencies and processing economy constraints can predict the acceptability of these three word-order variants, and whether subject raising and subject control verbs form clearly distinguishable subclasses of infinitive-embedding verbs in terms of their word-order behaviour. Secondly, our study looks into the issue of coherence by comparing acceptability ratings for monoclausal coherent and biclausal incoherent construals of intraposed infinitives, and by examining whether a biclausal incoherent analysis gives rise to local and/or global processing difficulty. Taken together, our results revealed that (i) whilst the extraposition pattern consistently wins out over all other word-order variants for control verbs, neither frequency nor processing-based approaches to word-order variation can account for the acceptability of low-frequency variants, (ii) there is considerable verb-specific variation regarding word-order preferences both between and within the two sets of raising and control verbs under investigation, and (iii) although monoclausal coherent intraposition is rated above biclausal incoherent intraposition, the latter is not any more difficult to process than the former. Our findings indicate that frequency of occurrence and processing-related constraints interact with idiosyncratic lexical properties of individual verbs in determining German speakers' structural preferences.
How to confuse motor control
(2023)
Adaptation to external forces relies on a well-functioning proprioceptive system including muscle spindle afferents. Muscle length and tension control in reaction to external forces is most important regarding the Adaptive Force (AF). This study investigated the effect of different procedures, which are assumed to influence the function of muscle spindles, on the AF. Elbow flexors of 12 healthy participants (n = 19 limbs) were assessed by an objectified manual muscle test (MMT) with different procedures: regular MMT, MMT after precontraction (self-estimated 20% MVIC) in lengthened position with passive return to test position (CL), and MMT after CL with a second precontraction in test position (CL-CT). During regular MMTs, muscles maintained their length up to 99.7% +/- 1.0% of the maximal AF (AF(max)). After CL, muscles started to lengthen at 53.0% +/- 22.5% of AF(max). For CL-CT, muscles were again able to maintain the static position up to 98.3% +/- 5.5% of AF(max). AFiso(max) differed highly significantly between CL vs. CL-CT and regular MMT. CL was assumed to generate a slack of muscle spindles, which led to a substantial reduction of the holding capacity. This was immediately erased by a precontraction in the test position. The results substantiate that muscle spindle sensitivity seems to play an important role for neuromuscular functioning and musculoskeletal stability.
Effects of exercise treatment on functional outcome parameters in mid-portion achilles tendinopathy
(2023)
Exercise interventions are evident in the treatment of mid-portion Achilles tendinopathy (AT). However, there is still a lack of knowledge concerning the effect of different exercise treatments on improving a specific function (e.g., strength) in this population. Thus, this study aimed to systematically review the effect of exercise treatments on different functional outcomes in mid-portion AT. An electronic database of Pubmed, Web of Science, and Cochrane Central Register of Controlled Trials were searched from inception to 21 February 2023. Studies that investigated changes in plantar flexor function with exercise treatments were considered in mid-portion AT. Only randomized controlled trials (RCTs) and clinical controlled trials (CCTs) were included. Functional outcomes were classified by kinetic (e.g., strength), kinematic [e.g., ankle range of motion (ROM)], and sensorimotor (e.g., balance index) parameters. The types of exercise treatments were classified into eccentric, concentric, and combined (eccentric plus concentric) training modes. Quality assessment was appraised using the Physiotherapy Evidence Database scale for RCTs, and the Joanna Briggs Institute scale for CCTs. The search yielded 2,260 records, and a total of ten studies were included. Due to the heterogeneity of the included studies, a qualitative synthesis was performed. Eccentric training led to improvements in power outcomes (e.g., height of countermovement jump), and in strength outcomes (e.g., peak torque). Concentric training regimens showed moderate enhanced power outcomes. Moreover, one high-quality study showed an improvement in the balance index by eccentric training, whereas the application of concentric training did not. Combined training modalities did not lead to improvements in strength and power outcomes. Plantarflexion and dorsiflexion ROM measures did not show relevant changes by the exercise treatments. In conclusion, eccentric training is evident in improving strength outcomes in AT patients. Moreover, it shows moderate evidence improvements in power and the sensorimotor parameter "balance index". Concentric training presents moderate evidence in the power outcomes and can therefore be considered as an alternative to improve this function. Kinematic analysis of plantarflexion and dorsiflexion ROM might not be useful in AT people. This study expands the knowledge what types of exercise regimes should be considered to improve the functional outcomes in AT.
High pressure and high temperature experiments performed with laser-heated diamond anvil cells (LH-DAC) are being extensively used in geosciences to study matter at conditions prevailing in planetary interiors. Due to the size of the apparatus itself, the samples that are produced are extremely small, on the order of few tens of micrometers. There are several ways to analyze the samples and extract physical, chemical or structural information, using either in situ or ex situ methods. In this paper, we compare two nanoprobe techniques, namely nano-XRF and NanoSIMS, that can be used to analyze recovered samples synthetized in a LH-DAC. With these techniques, it is possible to extract the spatial distribution of chemical elements in the samples. We show the results for several standards and discuss the importance of proper calibration for the acquisition of quantifiable results. We used these two nanoprobe techniques to retrieve elemental ratios of dilute species (few tens of ppm) in quenched experimental molten samples relevant for the formation of the iron-rich core of the Earth. We finally discuss the applications of such probes to constrain the partitioning of trace elements between metal and silicate phases, with a focus on moderately siderophile elements, tungsten and molybdenum.
We explore the role of non-ergodicity in the relationship between income inequality, the extent of concentration in the income distribution, and income mobility, the feasibility of an individual to change their position in the income rankings. For this purpose, we use the properties of an established model for income growth that includes 'resetting' as a stabilizing force to ensure stationary dynamics. We find that the dynamics of inequality is regime-dependent: it may range from a strictly non-ergodic state where this phenomenon has an increasing trend, up to a stable regime where inequality is steady and the system efficiently mimics ergodicity. Mobility measures, conversely, are always stable over time, but suggest that economies become less mobile in non-ergodic regimes. By fitting the model to empirical data for the income share of the top earners in the USA, we provide evidence that the income dynamics in this country is consistently in a regime in which non-ergodicity characterizes inequality and immobility. Our results can serve as a simple rationale for the observed real-world income dynamics and as such aid in addressing non-ergodicity in various empirical settings across the globe.This article is part of the theme issue 'Kinetic exchange models of societies and economies'.
IntroductionThe COVID-19 pandemic has huge influences on daily life and is not only associated with physical but also with major psychological impacts. Mental health problems and disorders are frequently present in elite paralympic athletes. Due to the pandemic situation, new stressors (e.g., loss of routine, financial insecurity) might act upon the athletes. Therefore, the assessment of mental health in athletes during the COVID-19 pandemic is important to identify prevalence of psychological problems and propose countermeasures. MethodsThe mental health of German paralympic athletes was longitudinally monitored (starting in May 2019). The athletes completed the Patient Health Questionnaire 4 (PHQ-4) on a weekly basis and reported a stress level, training hours, and training load. During the pandemic, 8 measurement time points (March 2020 to April 2021) were used to reflect the psychological health course of the athletes. In parallel, a convenience sample of the general population was questioned about their psychological distress, including the PHQ-4. To be included in the analysis, participants of both groups had to complete at least 4 measurement time points. Matching of the para-athletes and the general population sample was prioritized upon completion of the same measurement time points, gender, and age. ResultsSeventy-eight paralympic athletes (40 women, 38 men, age: 29.8 +/- 11.4 years) met the inclusion criteria. Seventy-eight matched pairs of the general population (40 women; 38 men; age: 30.5 +/- 10.9 years) were identified. The para-athletes had a significantly (p r <0.48) lower PHQ-4 value at each measurement time point compared to the matched control group. No significant age or sex differences were evident regarding the symptom burden. In para-athletes, no significant and a weak positive correlation was found between decreased training load and PHQ-4 values and a stress level, respectively. Reduced physical activity was significantly (p <0.0001) associated with higher PHQ-4 values in the general population sample. DiscussionLower PHQ-4 values were reported by the para-athletes compared to the general population sample. However, small sample sizes must be considered while interpreting the data. Nevertheless, adequate support for individuals suffering from severe psychopathological symptoms should be provided for para-athletes as well as for the general population.
Spatially explicit knowledge on grassland extent and management is critical to understand and monitor the impact of grassland use intensity on ecosystem services and biodiversity. While regional studies allow detailed insights into land use and ecosystem service interactions, information on a national scale can aid biodiversity assessments. However, for most European countries this information is not yet widely available. We used an analysis-ready-data cube that contains dense time series of co-registered Sentinel-2 and Landsat 8 data, covering the extent of Germany. We propose an algorithm that detects mowing events in the time series based on residuals from an assumed undisturbed phenology, as an indicator of grassland use intensity. A self-adaptive ruleset enabled to account for regional variations in land surface phenology and non-stationary time series on a pixelbasis. We mapped mowing events for the years from 2017 to 2020 for permanent grassland areas in Germany. The results were validated on a pixel level in four of the main natural regions in Germany based on reported mowing events for a total of 92 (2018) and 78 (2019) grassland parcels. Results for 2020 were evaluated with combined time series of Landsat, Sentinel-2 and PlanetScope data. The mean absolute percentage error between detected and reported mowing events was on average 40% (2018), 36% (2019) and 35% (2020). Mowing events were on average detected 11 days (2018), 7 days (2019) and 6 days (2020) after the reported mowing. Performance measures varied between the different regions of Germany, and lower accuracies were found in areas that are revisited less frequently by Sentinel-2. Thus, we assessed the influence of data availability and found that the detection of mowing events was less influenced by data availability when at least 16 cloud-free observations were available in the grassland season. Still, the distribution of available observations throughout the season appeared to be critical. On a national scale our results revealed overall higher shares of less intensively mown grasslands and smaller shares of highly intensively managed grasslands. Hotspots of the latter were identified in the alpine foreland in Southern Germany as well as in the lowlands in the Northwest of Germany. While these patterns were stable throughout the years, the results revealed a tendency to lower management intensity in the extremely dry year 2018. Our results emphasize the ability of the approach to map the intensity of grassland management throughout large areas despite variations in data availability and environmental conditions.
In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd-37th gestational week) and early preterm birth (20th-32nd gestational week). The underlying general and procedure related risk factors are not well understood so far. 4328 infertile women undergoing IVF/ICSI were entered into this study. The study population was divided into three groups: (a) early preterm birth group (n = 66), (b) preterm birth group (n = 675) and (c) full-term birth group (n = 3653). Odds for preterm birth were calculated by stepwise multivariate logistic regression analysis. We identified seven independent risk factors for preterm birth and four independent risk factors for early preterm birth. Older (> 39) or younger (< 25) maternal age (OR: 1.504, 95% CI 1.108-2.042, P = 0.009; OR: 2.125, 95% CI 1.049-4.304, P = 0.036, respectively), multiple pregnancy (OR: 9.780, 95% CI 8.014-11.935, P < 0.001; OR: 8.588, 95% CI 4.866-15.157, P < 0.001, respectively), placenta previa (OR: 14.954, 95% CI 8.053-27.767, P < 0.001; OR: 16.479, 95% CI 4.381-61.976, P < 0.001, respectively), and embryo reduction (OR: 3.547, 95% CI 1.736-7.249, P = 0.001; OR: 7.145, 95% CI 1.990-25.663, P = 0.003, respectively) were associated with preterm birth and early preterm birth, whereas gestational hypertension (OR: 2.494, 95% CI 1.770-3.514, P < 0.001), elevated triglycerides (OR: 1.120, 95% CI 1.011-1.240, P = 0.030) and shorter activated partial thromboplastin time (OR: 0.967, 95% CI 0.949-0.985, P < 0.001) were associated only with preterm birth. In conclusion, preterm and early preterm birth risk factors in patients undergoing assisted IVF/ICSI are in general similar to those in natural pregnancy. The lack of some associations in the early preterm group was most likely due to the lower number of early preterm birth cases. Only embryo reduction represents an IVF/ICSI specific risk factor.