Nathalie E. Holz, Regina Boecker-Schlier, Christine Jennen-Steinmetz, Erika Hohm, Arlette F. Buchmann, Dorothea Blomeyer, Sarah Baumeister, Michael M. Plichta, Günter Esser, Martin Schmidt, Andreas Meyer-Lindenberg, Tobias Banaschewski, Daniel Brandeis, Manfred Laucht
- Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated withReward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.…
MetadatenVerfasserangaben: | Nathalie E. Holz, Regina Boecker-Schlier, Christine Jennen-Steinmetz, Erika Hohm, Arlette F. Buchmann, Dorothea Blomeyer, Sarah Baumeister, Michael M. Plichta, Günter EsserORCiDGND, Martin Schmidt, Andreas Meyer-Lindenberg, Tobias BanaschewskiORCiD, Daniel Brandeis, Manfred LauchtGND |
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DOI: | https://doi.org/10.1093/scan/nsy087 |
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ISSN: | 1749-5016 |
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ISSN: | 1749-5024 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30257014 |
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Titel des übergeordneten Werks (Englisch): | Social Cognitive and Affective Neuroscience |
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Verlag: | Oxford Univ. Press |
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Verlagsort: | Oxford |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Erstveröffentlichung: | 25.09.2018 |
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Erscheinungsjahr: | 2018 |
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Datum der Freischaltung: | 02.07.2021 |
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Freies Schlagwort / Tag: | ADHD; aggression; fMRI; maternal care; resilience; ventral striatum |
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Band: | 13 |
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Ausgabe: | 11 |
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Seitenanzahl: | 11 |
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Erste Seite: | 1191 |
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Letzte Seite: | 1201 |
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Fördernde Institution: | German Research FoundationGerman Research Foundation (DFG) [DFG HO 5674/2-1]; Olympia Morata Programme of the Heidelberg University; EC FP7 project Aggressotype [FP7-Health-2013-Innovation-1 602805]; EC FP7 project MATRICS [FP7-Health-2013-Innovation-1 603016] |
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Organisationseinheiten: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Lizenz (Deutsch): | CC-BY - Namensnennung 4.0 International |
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