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Detecting carbohydrate–lectin interactions using a fluorescent probe based on DBD dyes

  • Herein we present an efficient synthesis of a biomimetic probe with modular construction that can be specifically bound by the mannose binding FimH protein – a surface adhesion protein of E. coli bacteria. The synthesis combines the new and interesting DBD dye with the carbohydrate ligand mannose via a Click reaction. We demonstrate the binding to E. coli bacteria over a large concentration range and also present some special characteristics of those molecules that are of particular interest for the application as a biosensor. In particular, the mix-and-measure ability and the very good photo-stability should be highlighted here.

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Metadaten
Author details:Pablo WessigORCiDGND, Denise Bader, Dennis Tobias KlierGND, Cornelia Hettrich, Frank Fabian BierORCiDGND
URN:urn:nbn:de:kobv:517-opus4-394382
Publication series (Volume number):Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (314)
Publication type:Postprint
Language:English
Date of first publication:2016/01/14
Publication year:2016
Publishing institution:Universität Potsdam
Release date:2017/03/30
Tag:assay; binding; conformational-changes; green-i; protein
Number of pages:4
First page:1235
Last Page:1238
Source:Analytical methods (2016) Nr. 8, S. 1235-1238. - DOI: 10.1039/C5AY02991K
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer review:Referiert
Publishing method:Open Access
License (English):License LogoCreative Commons - Namensnennung 3.0 Unported
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