The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 16 of 750
Back to Result List

A single nucleotide polymorphism near the CYP17A1 gene is associated with left ventricular mass in hypertensive patients under pharmacotherapy

  • Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this background, we investigated associations between single nucleotide polymorphisms (SNPs) in or nearby the CYP17A1 gene with BP and left ventricular mass in patients with arterial hypertension and associated cardiovascular organ damage treated according to guidelines. Patients (n = 1007, mean age 58.0 ± 9.8 years, 83% men) with arterial hypertension and cardiac left ventricular ejection fraction (LVEF) ≥40% were enrolled in the study. Cardiac parameters of left ventricular mass, geometry and function were determined by echocardiography. The cohort comprised patients with coronary heart disease (n = 823; 81.7%) and myocardialCytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this background, we investigated associations between single nucleotide polymorphisms (SNPs) in or nearby the CYP17A1 gene with BP and left ventricular mass in patients with arterial hypertension and associated cardiovascular organ damage treated according to guidelines. Patients (n = 1007, mean age 58.0 ± 9.8 years, 83% men) with arterial hypertension and cardiac left ventricular ejection fraction (LVEF) ≥40% were enrolled in the study. Cardiac parameters of left ventricular mass, geometry and function were determined by echocardiography. The cohort comprised patients with coronary heart disease (n = 823; 81.7%) and myocardial infarction (n = 545; 54.1%) with a mean LVEF of 59.9% ± 9.3%. The mean left ventricular mass index (LVMI) was 52.1 ± 21.2 g/m2.7 and 485 (48.2%) patients had left ventricular hypertrophy. There was no significant association of any investigated SNP (rs619824, rs743572, rs1004467, rs11191548, rs17115100) with mean 24 h systolic or diastolic BP. However, carriers of the rs11191548 C allele demonstrated a 7% increase in LVMI (95% CI: 1%–12%, p = 0.017) compared to non-carriers. The CYP17A1 polymorphism rs11191548 demonstrated a significant association with LVMI in patients with arterial hypertension and preserved LVEF. Thus, CYP17A1 may contribute to cardiac hypertrophy in this clinical condition.show moreshow less

Download full text files

  • phr333eng
    (1339KB)

    SHA-1:31b09df4df6c9700cb7897140ae838ae5b6d1da8

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author:Matthias Huber, Susanne Lezius, Rona Katharina ReibisORCiDGND, Andras Treszl, Dorota Kujawinska, Stefanie Jakob, Karl WegscheiderORCiDGND, Heinz VöllerORCiDGND, Reinhold Kreutz
URN:urn:nbn:de:kobv:517-opus4-400074
Series (Serial Number):Postprints der Universität Potsdam : Humanwissenschaftliche Reihe (333)
Document Type:Postprint
Language:English
Date of first Publication:2017/08/31
Publishing Institution:Universität Potsdam
Release Date:2017/08/31
Tag:clinical study; cytochrome P450 17A1 (Cyp17A1); genetics; heart; hypertension
Pagenumber:13
Source:International journal of molecular sciences 6 (2015) Nr. 8, S. 17456–17468. - DOI: 10.3390/ijms160817456
Organizational units:Humanwissenschaftliche Fakultät
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Peer Review:Referiert
Publication Way:Open Access
Grantor:Multidisciplinary Digital Publishing Institute (MDPI)
Licence (German):License LogoCreative Commons - Namensnennung, 4.0 International