Quantitative approach to the stochastics of bone remodeling
- During life bones constantly adapt their structure to their mechanical environment via a mechanically controlled process called bone remodeling. For trabecular bone, this process modifies the thickness of each trabecula leading occasionally to full resorption. We describe the irreversible dynamics of the trabecular thickness distribution (TTD) by means of a Markov chain discrete in space and time. By using thickness data from adult patients, we derive the transition probabilities in the chain. This allows a quantification, in terms of geometrical quantities, of the control of bone remodeling and thus to determine the evolution of the TTD with age.
| Author details: | Marco Rusconi, Angelo VallerianiORCiDGND, John William Chapman DunlopORCiDGND, Jürgen KurthsORCiDGND, Richard Weinkamer |
|---|---|
| DOI: | https://doi.org/10.1209/0295-5075/97/28009 |
| ISSN: | 0295-5075 |
| Title of parent work (English): | epl : a letters journal exploring the frontiers of physics |
| Publisher: | EDP Sciences |
| Place of publishing: | Mulhouse |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2012 |
| Publication year: | 2012 |
| Release date: | 2017/03/26 |
| Volume: | 97 |
| Issue: | 2 |
| Number of pages: | 6 |
| Funding institution: | Marie Curie "Early Stage Training on Biomimetic Systems" |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| Peer review: | Referiert |
