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Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies lessons from Drosophila melanogaster and Apis mellifera

  • The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and modulating various physiological and behavioral processes in both protostomes and deuterostomes. The specific functions of serotonin are mediated by its binding to and subsequent activation of membrane receptors. The vast majority of these receptors belong to the superfamily of G-protein-coupled receptors. We report here the in vivo expression pattern of a recently characterized 5-HT(1) receptor of the honeybee Apis mellifera (Am5-HT(1A)) in the mushroom bodies. In addition, we summarize current knowledge on the distribution of serotonin and serotonin receptor subtypes in the brain and specifically in the mushroom bodies of the fruit fly Drosophila melanogaster and the honeybee. Functional studies in these two species have shown that serotonergic signaling participates in various behaviors including aggression, sleep, circadian rhythms, responses to visual stimuli, and associative learning. The molecular, pharmacological, and functionalThe biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and modulating various physiological and behavioral processes in both protostomes and deuterostomes. The specific functions of serotonin are mediated by its binding to and subsequent activation of membrane receptors. The vast majority of these receptors belong to the superfamily of G-protein-coupled receptors. We report here the in vivo expression pattern of a recently characterized 5-HT(1) receptor of the honeybee Apis mellifera (Am5-HT(1A)) in the mushroom bodies. In addition, we summarize current knowledge on the distribution of serotonin and serotonin receptor subtypes in the brain and specifically in the mushroom bodies of the fruit fly Drosophila melanogaster and the honeybee. Functional studies in these two species have shown that serotonergic signaling participates in various behaviors including aggression, sleep, circadian rhythms, responses to visual stimuli, and associative learning. The molecular, pharmacological, and functional properties of identified 5-HT receptor subtypes from A. mellifera and D. melanogaster will also be summarized in this review.show moreshow less

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Metadaten
Author:Wolfgang BlenauORCiDGND, Markus Thamm
DOI:https://doi.org/10.1016/j.asd.2011.01.004
ISSN:1467-8039
Parent Title (English):Arthropod structure & development
Publisher:Elsevier
Place of publication:Oxford
Document Type:Review
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Apis mellifera; Drosophila melanogaster; G-protein-coupled receptor; Mushroom body; Serotonin
Volume:40
Issue:5
Page Number:14
First Page:381
Last Page:394
Funder:German Research Foundation (Research Training Group) [837, BL 469/7-1]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert