Anti-mosquito and antimicrobial nor-halimanoids, isocoumarins and an anilinoid from Tessmannia densiflora

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The nor-halimane diterpenoid tessmannic acid and its methyl, 2-methylisopropyl and 1-methylbutyl esters, the unusual isocoumarins 8-hydroxy-6-methoxy-3-pentylisocoumarin and 7-chloro-8-hydroxy-6-methoxy-3-pentylisocoumarin, and 5- pentyl-3-methoxy-N-butylaniline were isolated from the stem and root bark extracts of Tessmannia densiflora Harms (Caesalpiniaceae) that showed mosquito larvicidal activity. The structures were determined on interpretation of spectroscopic data. Tessmannic acid and its methyl ester exhibited antibacterial and antifungal activity. The compounds also caused high larvae and adult Anopheles gambiae mosquitoe mortality effects, and stronger mosquito repellency than that shown by the standard repellent DEET, hence indicating Tessmannia species to be potential sources of bioactive natural products.

Metadaten
Author details:	Charles Kihampa, Mayunga H. H. Nkunya, Cosam C. Joseph, Stephen M. Magesa, Ahmed Hassanali, Matthias Heydenreich ORCiD, Erich Kleinpeter ORCiD GND
URL:	http://www.sciencedirect.com/science/journal/00319422
DOI:	https://doi.org/10.1016/j.phytochem.2009.07.024
ISSN:	0031-9422
Publication type:	Article
Language:	English
Year of first publication:	2009
Publication year:	2009
Release date:	2017/03/25
Source:	Phytochemistry. - ISSN 0031-9422. - 70 (2009), 10, S. 1233 - 1238
Organizational units:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer review:	Referiert