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Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity

  • Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.

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Metadaten
Author:Maik Lange, Steffen Braune, Karola Luetzow, Klaus Richau, Nico Scharnagl, Marie Weinhart, Axel T. Neffe, Friedrich Jung, Rainer Haag, Andreas LendleinORCiDGND
DOI:https://doi.org/10.1002/marc.201200426
ISSN:1022-1336 (print)
Parent Title (English):Macromolecular rapid communications
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Year of first Publication:2012
Year of Completion:2012
Release Date:2017/03/26
Tag:hemocompatibility; poly(ethylene glycol); polyglycerol; polyimides; surface chemistry
Volume:33
Issue:17
Pagenumber:6
First Page:1487
Last Page:1492
Funder:Bundesministerium fur Bildung und Forschung (BMBF) through wPoly4Bio BB; Helmholtz Association through the Helmholtz Virtual Institute
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert