Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir
- An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems.
| Author details: | Piotr J. Cywinski, Krzysztof R. Idzik, Charles G. Cranfield, Rainer Beckert, Gerhard J. Mohr |
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| URL: | http://www.informaworld.com/openurl?genre=journal&issn=1061-0278 |
| DOI: | https://doi.org/10.1080/10610278.2010.506541 |
| ISSN: | 1061-0278 |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2010 |
| Publication year: | 2010 |
| Release date: | 2017/03/25 |
| Source: | Supramolecular chemistry. - ISSN 1061-0278. - 22 (2010), 10, S. 598 - 602 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
