• search hit 8 of 14
Back to Result List

Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir

  • An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems.

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Author:Piotr J. Cywinski, Krzysztof R. Idzik, Charles G. Cranfield, Rainer Beckert, Gerhard J. Mohr
Document Type:Article
Year of first Publication:2010
Year of Completion:2010
Release Date:2017/03/25
Source:Supramolecular chemistry. - ISSN 1061-0278. - 22 (2010), 10, S. 598 - 602
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert