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Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir

  • An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems.

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Metadaten
Author:Piotr J. Cywinski, Krzysztof R. Idzik, Charles G. Cranfield, Rainer Beckert, Gerhard J. Mohr
URL:http://www.informaworld.com/openurl?genre=journal&issn=1061-0278
DOI:https://doi.org/10.1080/10610278.2010.506541
ISSN:1061-0278
Document Type:Article
Language:English
Year of first Publication:2010
Year of Completion:2010
Release Date:2017/03/25
Source:Supramolecular chemistry. - ISSN 1061-0278. - 22 (2010), 10, S. 598 - 602
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert