Molecular recognition of the antiretroviral drug Abacavir
- Due to their optical and electro-conductive attributes, carbazole derivatives are interesting materials for a large range of biosensor applications. In this study, we present the synthesis routes and fluorescence evaluation of newly designed carbazole fluorosensors that, by modification with uracil, have a special affinity for antiretroviral drugs via either Watson–Crick or Hoogsteen base pairing. To an N-octylcarbazole-uracil compound, four different groups were attached, namely thiophene, furane, ethylenedioxythiophene, and another uracil; yielding four different derivatives. Photophysical properties of these newly obtained derivatives are described, as are their interactions with the reverse transcriptase inhibitors such as abacavir, zidovudine, lamivudine and didanosine. The influence of each analyte on biosensor fluorescence was assessed on the basis of the Stern–Volmer equation and represented by Stern–Volmer constants. Consequently we have demonstrated that these structures based on carbazole, with a uracil group, may beDue to their optical and electro-conductive attributes, carbazole derivatives are interesting materials for a large range of biosensor applications. In this study, we present the synthesis routes and fluorescence evaluation of newly designed carbazole fluorosensors that, by modification with uracil, have a special affinity for antiretroviral drugs via either Watson–Crick or Hoogsteen base pairing. To an N-octylcarbazole-uracil compound, four different groups were attached, namely thiophene, furane, ethylenedioxythiophene, and another uracil; yielding four different derivatives. Photophysical properties of these newly obtained derivatives are described, as are their interactions with the reverse transcriptase inhibitors such as abacavir, zidovudine, lamivudine and didanosine. The influence of each analyte on biosensor fluorescence was assessed on the basis of the Stern–Volmer equation and represented by Stern–Volmer constants. Consequently we have demonstrated that these structures based on carbazole, with a uracil group, may be successfully incorporated into alternative carbazole derivatives to form biosensors for the molecular recognition of antiretroviral drugs.…
Author details: | Krzysztof Ryszard Idzik, Piotr J. CywinskiORCiD, Charles G. Cranfield, Gerhard J. Mohr, Rainer Beckert |
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URN: | urn:nbn:de:kobv:517-opus4-430372 |
DOI: | https://doi.org/10.25932/publishup-43037 |
ISSN: | 1866-8372 |
Title of parent work (German): | Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe |
Subtitle (English): | towards the development of a novel carbazole-based fluorosensor |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (847) |
Publication type: | Postprint |
Language: | English |
Date of first publication: | 2020/03/13 |
Publication year: | 2011 |
Publishing institution: | Universität Potsdam |
Release date: | 2020/03/13 |
Tag: | HAART; HIV; antiretroviral drugs; base pairing; carbazole; fluorescence spectroscopy |
Issue: | 847 |
Number of pages: | 12 |
First page: | 1195 |
Last Page: | 1204 |
Source: | Journal of Fluorescence 21 (2011) 1195–1204 DOI:10.1007/s10895-010-0798-7 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät |
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten |
Peer review: | Referiert |
Publishing method: | Open Access |
License (German): | Creative Commons - Namensnennung-Nicht kommerziell 2.0 Generic |
External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |