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Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas

  • The use of CO2 as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (Rp-p), as compared with N2, for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline Rp-p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (Rp-p?=?0.76), maltose and sucrose (Rp-p?=?1.04), and maltose and lactose (Rp-p?=?0.74). Ion mobility mass spectrometry using CO2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.

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Author:Maira Fasciotti, Gustavo B. Sanvido, Vanessa G. Santos, Priscila M. Lalli, Michael McCullagh, Gilberto F. de Sa, Romeu J. Daroda, Martin G. Peter, Marcos N. Eberlin
ISSN:1076-5174 (print)
Parent Title (English):Journal of mass spectrometr
Place of publication:Hoboken
Document Type:Article
Year of first Publication:2012
Year of Completion:2012
Release Date:2017/03/26
Tag:isomer resolution; oligosaccharides; polarizable drift gases; traveling wave ion mobility mass spectrometry
First Page:1643
Last Page:1647
Funder:Brazilian science foundation FAPESP; Brazilian science foundation CNPq; Brazilian science foundation CAPES; Brazilian science foundation FINEP
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert