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An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses

  • Interindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that theInterindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that the neurobiological mechanisms linking early adverse experience and later neuroendocrine stress regulation are modulated by a gene variant whose functional relevance is documented by increasing convergent evidence from in vitro, animal and human studies.show moreshow less

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Metadaten
Author:Stephanie H. Witt, Arlette F. Buchmann, Dorothea Blomeyer, Vanessa Nieratschker, Jens Treutlein, Günter EsserGND, Martin H. Schmidt, Martin Bidlingmaier, Klaus Wiedemann, Marcella Rietschel, Manfred Laucht, Stefan Wuest, Ulrich S. Zimmermann
DOI:https://doi.org/10.1016/j.psyneuen.2010.12.015
ISSN:0306-4530 (print)
Parent Title (English):Psychoneuroendocrinology
Publisher:Elsevier
Place of publication:Oxford
Document Type:Article
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Early adversity; GxE interaction; HPA; Neuropeptide Y; Stress
Volume:36
Issue:7
Pagenumber:11
First Page:1010
Last Page:1020
Funder:NGFNplus; German Research Foundation DFG [SFB636/Z4]
Organizational units:Humanwissenschaftliche Fakultät / Institut für Psychologie
Peer Review:Referiert