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Minimal intervention strategies in logical signaling networks with ASP

  • Proposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.

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Metadaten
Author details:Roland KaminskiORCiD, Torsten H. SchaubORCiDGND, Anne SiegelORCiDGND, Santiago Videla
URN:urn:nbn:de:kobv:517-opus4-415704
DOI:https://doi.org/10.25932/publishup-41570
ISSN:1866-8372
Title of parent work (English):Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
Publication series (Volume number):Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (596)
Publication type:Postprint
Language:English
Date of first publication:2019/02/13
Publication year:2013
Publishing institution:Universität Potsdam
Release date:2019/02/13
Tag:circuits; models; sets; systems biology; transduction
Issue:4-5
Number of pages:16
First page:675
Last Page:690
Source:Theory and Practice of Logic Programming 13 (2013) 4-5, pp.675–690 DOI 10.1017/S1471068413000422
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät
DDC classification:0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik
Peer review:Referiert
Publishing method:Open Access
Grantor:Cambridge University Press (CUP)
License (German):License LogoKeine öffentliche Lizenz: Unter Urheberrechtsschutz
External remark:Bibliographieeintrag der Originalveröffentlichung/Quelle
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