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Poly(ethylene glycol) grafting to Poly(ether imide) membranes - influence on protein adsorption and Thrombocyte adhesion

  • The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) membranes by grafting with monoamino PEG of different chain lengths (M-n=1kDa or 10kDa) and end groups (methoxy or hydroxyl) is proven by spectroscopy, changes of surface hydrophilicity, and surface shielding effects. The surface functionalization does lead to reduction of adsorption of BSA, but not of fibrinogen. The thrombocyte adhesion is increased compared to untreated PEI surfaces. Conclusively, rough instead of smooth polymer or gold surfaces should be investigated as relevant models.

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Metadaten
Author:Axel T. Neffe, Maik von Rüsten-Lange, Steffen Braune, Karola Lützow, Toralf Roch, Klaus Richau, Friedrich Jung, Andreas LendleinORCiDGND
DOI:https://doi.org/10.1002/mabi.201300309
ISSN:1616-5187 (print)
ISSN:1616-5195 (online)
Parent Title (English):Macromolecular bioscience
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:biomaterials; poly(ethylene glycol); protein adsorption; surface functionalization; thrombocyte adhesion
Volume:13
Issue:12
Pagenumber:10
First Page:1720
Last Page:1729
Funder:Bundesministerium fur Bildung und Forschung (BMBF) [0315696A]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert