Quantification of spatial structure of human proximal tibial bone biopsies using 3D measures of complexity

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Changes in trabecular bone composition during development of osteoporosis are used as a model for bone loss in microgravity conditions during a space flight. Symbolic dynamics and measures of complexity are proposed and applied to assess quantitatively the structural composition of bone tissue from 3D data sets of human tibia bone biopsies acquired by a micro-CT scanner. In order to justify the newly proposed approach, the measures of complexity of the bone architecture were compared with the results of traditional 2D bone histomorphometry. The proposed technique is able to quantify the structural loss of the bone tissue and may help to diagnose and to monitor changes in bone structure of patients on Earth as well as of the space-flying personnel. © 2005 Elsevier Ltd. All rights reserved

Metadaten
Author details:	P. I. Saparin, J. S. Thomsen, Steffen Prohaska, Alexei Zaikin GND, Jürgen Kurths ORCiD GND, H. C. Hege, W. Gowin
ISSN:	0094-5765
Publication type:	Article
Language:	English
Year of first publication:	2005
Publication year:	2005
Release date:	2017/03/24
Source:	Acta Astronautica. - ISSN 0094-5765. - 56 (2005), 9-12, S. 820 - 830
Organizational units:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie
Peer review:	Referiert
Institution name at the time of the publication:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik