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An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana

  • In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor Regulator of Proteasomal Gene Expression' (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis-element recognized by RPX is evolutionarily conserved between higher plant species. Upon over-expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.

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Author:Hung M. Nguyen, Jos H. M. Schippers, Oscar Goni-Ramos, Mathias P. Christoph, Hakan Dortay, Renier A. L. van der Hoorn, Bernd Müller-RöberORCiDGND
ISSN:0960-7412 (print)
Parent Title (English):The plant journal
Place of publication:Hoboken
Document Type:Article
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:Arabidopsis thaliana; evolution; gene regulatory network; leaf development; organ size; proteasome
First Page:25
Last Page:36
Funder:Bundesministerium fur Bildung und Forschung; FKZ [0313924]; Vietnam Ministry of Education and Training; Max Planck Society
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert