- search hit 1 of 1
Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus
- From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.
| Author details: | Leonidah Omosa Kerubo, Jacob Ogweno Midiwo, Solomon DereseORCiD, Moses K. Langat, Hoseah M. AkalaORCiD, Norman C. Waters, Martin Peter, Matthias HeydenreichORCiD |
|---|---|
| ISSN: | 1934-578X |
| Title of parent work (English): | Natural product communications : an international journal for communications and reviews |
| Publisher: | NPC |
| Place of publishing: | Westerville |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2013 |
| Publication year: | 2013 |
| Release date: | 2017/03/26 |
| Tag: | Antiplasmodial activity; Asteraceae; Senecio roseiflorus; Surface exudates |
| Volume: | 8 |
| Issue: | 2 |
| Number of pages: | 2 |
| First page: | 175 |
| Last Page: | 176 |
| Funding institution: | German Academic Exchange Service (DAAD); Deutsche Forschungsgemeinschaft, Germany [Pe 264/ 14-5]; Bundesministerium fur Zusammenarbeit [Pe-254/14-6] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
