Optimal length transportation hypothesis to model proteasome product size distribution
- This paper discusses translocation features of the 20S proteasome in order to explain typical proteasome length distributions. We assume that the protein transport depends significantly on the fragment length with some optimal length which is transported most efficiently. By means of a simple one-channel model, we show that this hypothesis can explain both the one- and the three-peak length distributions found in experiments. A possible mechanism of such translocation is provided by so-called fluctuation-driven transport.
| Author details: | Alexey ZaikinGND, Jürgen KurthsORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1007/s10867-006-9014-z |
| ISSN: | 0092-0606 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/19669465 |
| Title of parent work (English): | Journal of biological physics : emphasizing physical principles in biological research ; an international journal for the formulation and application of mathematical models in the biological sciences |
| Publisher: | Springer |
| Place of publishing: | Dordrecht |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2006/10/26 |
| Publication year: | 2006 |
| Release date: | 2020/05/12 |
| Tag: | proteasome; protein translocation; ratchets; stochastic process |
| Volume: | 32 |
| Issue: | 3-4 |
| Number of pages: | 13 |
| First page: | 231 |
| Last Page: | 243 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
| Peer review: | Referiert |
| Publishing method: | Open Access |
| Open Access / Green Open-Access | |
| Institution name at the time of the publication: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik |
