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Synthetic multicellular oscillatory systems controlling protein dynamics with genetic circuits

  • Synthetic biology is a relatively new research discipline that combines standard biology approaches with the constructive nature of engineering. Thus, recent efforts in the field of synthetic biology have given a perspective to consider cells as 'programmable matter'. Here, we address the possibility of using synthetic circuits to control protein dynamics. In particular, we show how intercellular communication and stochasticity can be used to manipulate the dynamical behavior of a population of coupled synthetic units and, in this manner, finely tune the expression of specific proteins of interest, e.g. in large bioreactors.

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Author details:Aneta Koseska, Evgenii Volkov, Jürgen KurthsORCiDGND
DOI:https://doi.org/10.1088/0031-8949/84/04/045007
ISSN:0031-8949
Title of parent work (English):Physica scripta : an international journal for experimental and theoretical physics
Publisher:IOP Publ. Ltd.
Place of publishing:Bristol
Publication type:Article
Language:English
Year of first publication:2011
Publication year:2011
Release date:2017/03/26
Volume:84
Issue:4
Number of pages:10
Funding institution:Federal Ministry of Education and Research [0313924]; RFBR [11-01-00392]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie
Peer review:Referiert
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