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Quantum dot biosensors for ultrasensitive multiplexed diagnostics

  • Time- and color-resolved detection of Foerster resonance energy transfer (FRET) from luminescent terbium complexes to different semiconductor quantum dots results in a fivefold multiplexed bioassay with sub-picomolar detection limits for all five bioanalytes (see picture). The detection of up to five biomarkers occurs with a sensitivity that is 40-240-fold higher than one of the best-established single-analyte reference assays.

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Author:Daniel Geißler, Loïc J. Charbonnière, Raymond F. Ziessel, Nathaniel G. Butlin, Hans-Gerd LöhmannsröbenGND, Niko Hildebrandt
Document Type:Article
Year of first Publication:2010
Year of Completion:2010
Release Date:2017/03/25
Source:Angewandte Chemie : international edition. - ISSN 1433-7851. - 49 (2010), 8, S. 1396 - 1401
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert