Quantum dot biosensors for ultrasensitive multiplexed diagnostics
- Time- and color-resolved detection of Foerster resonance energy transfer (FRET) from luminescent terbium complexes to different semiconductor quantum dots results in a fivefold multiplexed bioassay with sub-picomolar detection limits for all five bioanalytes (see picture). The detection of up to five biomarkers occurs with a sensitivity that is 40-240-fold higher than one of the best-established single-analyte reference assays.
| Author details: | Daniel Geißler, Loïc J. Charbonnière, Raymond F. Ziessel, Nathaniel G. Butlin, Hans-Gerd LöhmannsröbenORCiDGND, Niko HildebrandtGND |
|---|---|
| URL: | http://www3.interscience.wiley.com/cgi-bin/jhome/26737/ |
| DOI: | https://doi.org/10.1002/anie.200906399 |
| ISSN: | 1433-7851 |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2010 |
| Publication year: | 2010 |
| Release date: | 2017/03/25 |
| Source: | Angewandte Chemie : international edition. - ISSN 1433-7851. - 49 (2010), 8, S. 1396 - 1401 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
