Comparison of metabolite profiles in U87 glioma cells and mesenchymal stem cells
- Gas chromatography-mass spectrometry (GC-MS) profiles were generated from U87 glioma cells and human mesenchymal stem cells (hMSC). 37 metabolites representing glycolysis intermediates, TCA cycle metabolites, amino acids and lipids were selected for a detailed analysis. The concentrations of these. metabolites were compared and Pearson correlation coefficients were used to calculate the relationship between pairs of metabolites. Metabolite profiles and correlation patterns differ significantly between the two cell lines. These profiles can be considered as a signature of the underlying biochemical system and provide snap-shots of the metabolism in mesenchymal stem cells and tumor cells.
| Author details: | Kathrin Juerchott, Ke-Tai Guo, Gareth Catchpole, Kristen Feher, Lothar WillmitzerORCiDGND, Christian Schichor, Joachim SelbigGND |
|---|---|
| DOI: | https://doi.org/10.1016/j.biosystems.2011.05.005 |
| ISSN: | 0303-2647 |
| Title of parent work (English): | Biosystems : journal of biological and information processing sciences |
| Publisher: | Elsevier |
| Place of publishing: | Oxford |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2011 |
| Publication year: | 2011 |
| Release date: | 2017/03/26 |
| Tag: | Correlation networks; Human mesenchymal stem cells; Metabolite profiles; U87 glioma cells |
| Volume: | 105 |
| Issue: | 2 |
| Number of pages: | 10 |
| First page: | 130 |
| Last Page: | 139 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
