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Synthesis and conformational analysis of naphth[1,2-e][1,3]oxazino[4,3-a][1,3]isoquinoline and naphth[2,1- e][1,3]oxazino[4,3-a]isoquinoline derivatives

  • Through the cyclization of 1-(;-hydroxynaphthyl)-1,2,3,4-tetrahydroisoquinoline and 1-(;- hydroxynaphthyl)-1,2,3,4-tetrahydroisoquinoline with formaldehyde, phosgene, p-nitrobenzaldehyde or p-chlorophenyl isothiocyanate, 8-substituted 10,11-dihydro-8H,15bH-naphth[1,2-e][1,3]oxazino[4,3-a]isoquinolines (3 and 4) and 10,11- dihydro-8H,15bH-naphth[2,1-e][1,3]oxazino[4,3-a]isoquinolines (15 and 16) were prepared. Conformational analysis of both the piperidine and the 1,3-oxazine moieties of these heterocycles by NMR spectroscopy and an accompanying theoretical study revealed that these two conformationally flexible six-membered ring moieties prefer twisted chair conformers.

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Author details:Matthias HeydenreichORCiD, Andreas KochORCiDGND, István SzatmáriORCiD, Ferenc FulopORCiD, Erich KleinpeterORCiDGND
URL:http://www.sciencedirect.com/science/article/pii/S0040402008009150
DOI:https://doi.org/10.1016/j.tet.2008.05.025
Publication type:Article
Language:English
Year of first publication:2008
Publication year:2008
Release date:2017/03/24
Source:Tetrahedron. - 64 (2008), 30-31, S. 7378 - 7385
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
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