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Cerebral activation evoked by the mirror illusion of the hand in stroke patients compared to normal subjects

  • BACKGROUND: Mirror therapy (MT) was found to improve motor function after stroke, but its neural mechanisms remain unclear, especially in single stroke patients. OBJECTIVES: The following imaging study was designed to compare brain activation patterns evoked by the mirror illusion in single stroke patients with normal subjects. METHODS: Fifteen normal volunteers and five stroke patients with severe arm paresis were recruited. Cerebral activations during movement mirroring by means of a video chain were recorded with functional magnetic resonance imaging (fMRI). Single-subject analysis was performed using SPM 8. RESULTS: For normal subjects, ten and thirteen subjects displayed lateralized cerebral activations evoked by the mirror illusion while moving their right and left hand respectively. The magnitude of this effect in the precuneus contralateral to the seen hand was not dependent on movement speed or subjective experience. Negative correlation of activation strength with age was found for the right hand only. The activationBACKGROUND: Mirror therapy (MT) was found to improve motor function after stroke, but its neural mechanisms remain unclear, especially in single stroke patients. OBJECTIVES: The following imaging study was designed to compare brain activation patterns evoked by the mirror illusion in single stroke patients with normal subjects. METHODS: Fifteen normal volunteers and five stroke patients with severe arm paresis were recruited. Cerebral activations during movement mirroring by means of a video chain were recorded with functional magnetic resonance imaging (fMRI). Single-subject analysis was performed using SPM 8. RESULTS: For normal subjects, ten and thirteen subjects displayed lateralized cerebral activations evoked by the mirror illusion while moving their right and left hand respectively. The magnitude of this effect in the precuneus contralateral to the seen hand was not dependent on movement speed or subjective experience. Negative correlation of activation strength with age was found for the right hand only. The activation pattern in stroke patients is comparable to that of normal subjects and present in four out of five patients. CONCLUSIONS: In summary, the mirror illusion can elicit cerebral activation contralateral to the perceived hand in the majority of single normal subjects, but not in all of them. This is similar even in stroke patients with severe hemiparesis.show moreshow less

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Metadaten
Author:Jing Wang, Claire Fritzsch, Johannes Bernarding, Thomas Krause, Karl-Heinz Mauritz, Maddalena Brunetti, Christian Dohle
DOI:https://doi.org/10.3233/NRE-130999
ISSN:1053-8135 (print)
ISSN:1878-6448 (online)
Parent Title (English):Neurorehabilitation : an interdisciplinary journal
Publisher:IOS Press
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:Movement; imaging; mirror illusion; mirror therapy; stroke
Volume:33
Issue:4
Pagenumber:11
First Page:593
Last Page:603
Funder:National Natural Science Foundation of China (NSFC) [81201504]; Zhejiang Provincial National Science Foundation of China [LY12H17004]; Center of Stroke Research Berlin (FlexFunds) [CS-2009-10]; Gesellschaft zur Forderung der Neurologischen Rehabilitation
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert