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The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

  • SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.

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Metadaten
Author:Monika Jedrusik-Bode, Maja Studencka, Christian Smolka, Tobias Baumann, Henning Schmidt, Jan Kampf, Franziska Paap, Sophie Martin, Jamal Tazi, Kristian M. Müller, Marcus Krüger, Thomas Braun, Eva Bober
DOI:https://doi.org/10.1242/jcs.130708
ISSN:0021-9533 (print)
ISSN:1477-9137 (online)
Parent Title (English):Journal of cell science
Publisher:Company of Biologists Limited
Place of publication:Cambridge
Document Type:Article
Language:English
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:C. elegans; G3BP; SIRT6; Sirtuins; Stress; Stress granules
Volume:126
Issue:22
Pagenumber:20
First Page:5166
Last Page:+
Funder:German National Funding Agency (DFG) [JE 505/1-3]; Max Planck Society; Fondation pour la Recherche Medicale (FRM) [DEQ20111223745]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert