Aqueous Self-Assembly of Purely Hydrophilic Block Copolymers into Giant Vesicles
- Self-assembly of macromolecules is fundamental to life itself, and historically, these systems have been primitively mimicked by the development of amphiphilic systems, driven by the hydrophobic effect. Herein, we demonstrate that self-assembly of purely hydrophilic systems can be readily achieved with similar ease and success. We have synthesized double hydrophilic block copolymers from polysaccharides and poly(ethylene oxide) or poly(sarcosine) to yield high molar mass diblock copolymers through oxime chemistry. These hydrophilic materials can easily assemble into nanosized (<500nm) and microsized (>5m) polymeric vesicles depending on concentration and diblock composition. Because of the solely hydrophilic nature of these materials, we expect them to be extraordinarily water permeable systems that would be well suited for use as cellular mimics.
Author details: | Sarah M. Brosnan, Helmut SchlaadORCiDGND, Markus AntoniettiORCiDGND |
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DOI: | https://doi.org/10.1002/anie.201502100 |
ISSN: | 1433-7851 |
ISSN: | 1521-3773 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/26140384 |
Title of parent work (English): | Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Year of first publication: | 2015 |
Publication year: | 2015 |
Release date: | 2017/03/27 |
Tag: | block copolymers; polymersomes; polysaccharides; self-assembly; vesicles |
Volume: | 54 |
Issue: | 33 |
Number of pages: | 4 |
First page: | 9715 |
Last Page: | 9718 |
Funding institution: | National Science Foundation (NSF) [DBI-1308104]; Max Planck Society |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |