Structure and function of chitinolytic enzymes
- The recent work on a variety of family 18 chitonolytic enzymes has yielded important data concerning the structure, substrate-binding, catalysis, inhibitor-binding and even dynamics. These data have been useful in helping to better understand the roles of various types of chitinases in chitin hydrolysis, to rationally engineer the properties of these enzymes, thus making them more suitable as biocatalysts, and to study and understand the effectiveness of natural and designed chitinase inhibitors, which may be of medical interest. On the other hand, the recent work on ChiB shows that catalysis in family 18 chitinases is a highly complicated process, involving larger parts of the enzyme and dynamics. Thus, despite recent discoveries, there is still a lot more to discover about how these enzyme work.
| Author details: | Vincent G. H. Eijsink, Bjoenar Synstad, Sigrid Gaseidnes, David Komander, Douglas R. Houston, Martin G. Peter, Daan M. F. van Aalten |
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| ISBN: | 82-471-5901-5 |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2003 |
| Publication year: | 2003 |
| Release date: | 2017/03/24 |
| Source: | Proceedings from the 5th International Conference of the European Chitin Society held in Trondheim / Hrsg.: Vaarum, Kjell; Domard, Alain; Smidroed, Olav. - Trondheim : NTU, 2003. - ISBN: 82-471-5901-5. - (Advances in chitin science ; 6). - S. 71 - 78 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
