New molecular rods - Characterization of their interaction with membranes
- Molecular rods are synthetical molecules consisting of a hydrophobic backbone which are functionalized with varying terminal groups. Here, we report on the interaction of a recently described new class of molecular rods with lipid and biological membranes. In order to characterize this interaction, different fluorescently labeled rods were synthesized allowing for the application of fluorescence spectroscopy and microscopy based approaches. Our data show that the rods are incorporated into membranes with a perpendicular orientation to the membrane surface and enrich preferentially in liquid-disordered lipid domains. These characteristics underline that rods can be applied as stable membrane-associated anchors for functionalizing membrane surfaces.
| Author details: | Jörg Nikolaus, Sylvia Czapla, Kristian Möllnitz, Chris T. Höfer, Andreas HerrmannORCiD, Pablo WessigORCiDGND, Peter Müller |
|---|---|
| DOI: | https://doi.org/10.1016/j.bbamem.2011.08.008 |
| ISSN: | 0005-2736 |
| Title of parent work (English): | Biochimica et biophysica acta : Biomembranes |
| Publisher: | Elsevier |
| Place of publishing: | Amsterdam |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2011 |
| Publication year: | 2011 |
| Release date: | 2017/03/26 |
| Tag: | Lipid domain; Molecular rod; Phospholipid; Spiro compound |
| Volume: | 1808 |
| Issue: | 12 |
| Number of pages: | 8 |
| First page: | 2781 |
| Last Page: | 2788 |
| Funding institution: | Deutsche Forschungsgemeinschaft [WE 1850/7-1, WE 1850/7-2, SFB 765] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
