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Cytochrome P450 biosensors : a review

  • Cytochrome P450 (CYP) is a large family of enzymes containing heme as the active site. Since their discovery and the elucidation of their structure, they have attracted the interest of scientist for many years, particularly due to their catalytic abilities. Since the late 1970s attempts have concentrated on the construction and development of electrochemical sensors. Although sensors based on mediated electron transfer have also been constructed, the direct electron transfer approach has attracted most of the interest. This has enabled the investigation of the electrochemical properties of the various isoforms of CYP. Furthermore, CYP utilized to construct biosensors for the determination of substrates important in environmental monitoring, pharmaceutical industry and clinical practice. (c) 2004 Elsevier B. V. All rights reserved

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Author:Nikitas Bistolas, Ursula WollenbergerORCiDGND, Christiane Jung, Frieder W. SchellerORCiDGND
Document Type:Article
Year of first Publication:2005
Year of Completion:2005
Release Date:2017/03/24
Source:Biosensors & Bioelectronics. - 20 (2005), 12, S. 2408 - 2423
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert