Antiplasmodial and larvicidal flavonoids from Derris trifoliata
- From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
Author details: | Martin G. Peter, Abiy YenesewORCiD, Hannington Twinomuhwezi, Jacques M. Kabaru, Hoseah M. AkalaORCiD, Bernard T. Kiremire, Matthias HeydenreichORCiD, Fredrick Eyase, Norman C. Waters, Douglas S. Walsh |
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URN: | urn:nbn:de:kobv:517-opus-44614 |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 121) |
Publication type: | Postprint |
Language: | English |
Publication year: | 2009 |
Publishing institution: | Universität Potsdam |
Release date: | 2010/07/06 |
Tag: | (S)-Lupinifolin 4´-methyl ether; Derris trifoliata; Flavanone; Leguminosae; Lupinifolin |
Source: | Bulletin of the Chemical Society of Ethiopia 23 (2009), 3, S. 409 - 414 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
External remark: | The article was originally published by: The Chemical Society of Ethiopia Bulletin of the Chemical Society of Ethiopia. - 23 (2009), 3, S. 409-414 ISSN 1011-3924 |