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Silicification of peptide-coated silver nanoparticles-A biomimetic soft chemistry approach toward chiral hybrid core-shell materials

  • Silica and silver nanoparticles are relevant materials for new applications in optics, medicine, and analytical chemistry. We have previously reported the synthesis of pH responsive, peptide-templated, chiral silver nanoparticles. The current report shows that peptide-stabilized nanoparticles can easily be coated with a silica shell by exploiting the ability of the peptide coating to hydrolyze silica precursors such as TEOS or TMOS. The resulting silica layer protects the nanoparticles from chemical etching, allows their inclusion in other materials, and renders them biocompatible. Using electron and atomic force microscopy, we show that the silica shell thickness and the particle aggregation can be controlled simply by the reaction time. Small-angle X ray scattering confirms the Ag/peptide@silica core-shell structure. UV-vis and circular dichroism spectroscopy prove the conservation of the silver nanoparticle chirality upon silicification. Biological tests show that the biocompatibility in simple bacterial systems is significantlySilica and silver nanoparticles are relevant materials for new applications in optics, medicine, and analytical chemistry. We have previously reported the synthesis of pH responsive, peptide-templated, chiral silver nanoparticles. The current report shows that peptide-stabilized nanoparticles can easily be coated with a silica shell by exploiting the ability of the peptide coating to hydrolyze silica precursors such as TEOS or TMOS. The resulting silica layer protects the nanoparticles from chemical etching, allows their inclusion in other materials, and renders them biocompatible. Using electron and atomic force microscopy, we show that the silica shell thickness and the particle aggregation can be controlled simply by the reaction time. Small-angle X ray scattering confirms the Ag/peptide@silica core-shell structure. UV-vis and circular dichroism spectroscopy prove the conservation of the silver nanoparticle chirality upon silicification. Biological tests show that the biocompatibility in simple bacterial systems is significantly improved once a silica layer is deposited on the silver particles.show moreshow less

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Metadaten
Author:Philipp Graf, Alexandre Mantion, Andrea Haase, Andreas F. Thuenemann, Admir Masic, Wolfgang P. Meier, Andreas Luch, Andreas TaubertORCiDGND
DOI:https://doi.org/10.1021/nn102969p
ISSN:1936-0851 (print)
Parent Title (English):ACS nano
Publisher:American Chemical Society
Place of publication:Washington
Document Type:Article
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Ag/peptide@SiO(2) nanostructures; chiral nanoparticles; core-shell structures; peptide-templated materials; silver nanoparticles
Volume:5
Issue:2
Pagenumber:14
First Page:820
Last Page:833
Funder:Adolf-Martens e.V.; Alexander von Humboldt Foundation; Max Planck Society; Federal Ministry of Education and Research; Swiss National Science Foundation; University of Potsdam; Fonds der Chemischen Industrie; Bundesanstalt fur Materialforschung und -prufung; Bundesinstitut fur Risikobewertung; MPI of Colloids and Interfaces (Colloid Chemistry Department)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert