The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts
- The antibiotic fungal metabolite sinefungin is a potent inhibitor of S-adenosylmethionine-acceptor methyltransferases. Its effect on insect metabolism and especially on corpora allata farnesoic acid methyltransferase, which catalyzes the penultimate step of juvenile hormone biosynthesis, was investigated in Locusta migratoria. Injection of sinefungin results in a delay of imaginal molt and in suppression of ovary development. Isolated corpora allata are unable to synthesize juvenile hormone III in the presence of more than 1.0 mM sinefungin. In a cell-free system containing the S-adenosylmethionine-dependent farnesoic acid methyltransferase from corpora allata sinefungin is a competitive inhibitor of the synthesis of methylfarnesoate with Ki of 1 μM.
Author details: | Hans-Jörg Ferenz, Martin G. Peter |
---|---|
URN: | urn:nbn:de:kobv:517-opus-16811 |
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 076) |
Publication type: | Postprint |
Language: | English |
Publication year: | 1987 |
Publishing institution: | Universität Potsdam |
Release date: | 2008/09/17 |
Tag: | Locust; O-methyltransferase; juvenile hormone biosynthesis; sinefungin |
Source: | Insect Biochemistry. - 17 (1987), 7, pp. 1119-1122. - ISSN 0020-1790 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
External remark: | first published in: Insect Biochemistry. - 17 (1987), 7, pp. 1119-1122 ISSN 0020-1790 DOI 10.1016/0020-1790(87)90132-6 |