Construction of highly ordered glyco-inside nano-assemblies through RAFT dispersion polymerization of galactose-decorated monomer
- Glyco-assemblies derived from amphiphilic sugar-decorated block copolymers (ASBCs) have emerged prominently due to their wide application, for example, in biomedicine and as drug carriers. However, to efficiently construct these glyco-assemblies is still a challenge. Herein, we report an efficient technology for the synthesis of glyco-inside nano-assemblies by utilizing RAFT polymerization of a galactose-decorated methacrylate for polymerization-induced self-assembly (PISA). Using this approach, a series of highly ordered glyco-inside nano-assemblies containing intermediate morphologies were fabricated by adjusting the length of the hydrophobic glycoblock and the polymerization solids content. A specific morphology of complex vesicles was captured during the PISA process and the formation mechanism is explained by the morphology of its precursor and intermediate. Thus, this method establishes a powerful route to fabricate glyco-assemblies with tunable morphologies and variable sizes, which is significant to enable the large-scaleGlyco-assemblies derived from amphiphilic sugar-decorated block copolymers (ASBCs) have emerged prominently due to their wide application, for example, in biomedicine and as drug carriers. However, to efficiently construct these glyco-assemblies is still a challenge. Herein, we report an efficient technology for the synthesis of glyco-inside nano-assemblies by utilizing RAFT polymerization of a galactose-decorated methacrylate for polymerization-induced self-assembly (PISA). Using this approach, a series of highly ordered glyco-inside nano-assemblies containing intermediate morphologies were fabricated by adjusting the length of the hydrophobic glycoblock and the polymerization solids content. A specific morphology of complex vesicles was captured during the PISA process and the formation mechanism is explained by the morphology of its precursor and intermediate. Thus, this method establishes a powerful route to fabricate glyco-assemblies with tunable morphologies and variable sizes, which is significant to enable the large-scale fabrication and wide application of glyco-assemblies.…
Author details: | Liang QiuORCiD, Haoran Zhang, Thomas Bick, Johannes MartinORCiDGND, Petra WendlerORCiDGND, Alexander BökerORCiDGND, Ulrich GlebeORCiDGND, Chengfen Xing |
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DOI: | https://doi.org/10.1002/anie.202015692 |
ISSN: | 1433-7851 |
ISSN: | 1521-3773 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33565244 |
Title of parent work (English): | Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Date of first publication: | 2021/02/09 |
Publication year: | 2021 |
Release date: | 2024/01/18 |
Tag: | PISA; RAFT dispersion polymerization; evolution; galactose-decorated monomer; glyco-inside nano-assemblies; morphology |
Volume: | 60 |
Issue: | 20 |
Number of pages: | 6 |
First page: | 11098 |
Last Page: | 11103 |
Funding institution: | Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [B2018202069, B2020202062, B2020202086]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21773054, 21905072, 22077025]; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence StrategyGerman Research Foundation (DFG) [EXC 2008-390540038-UniSysCat]; Projekt DEAL |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie | |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |
License (German): | CC-BY - Namensnennung 4.0 International |