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Antiplasmodial activity of compounds from the surface exudates of senecio roseiflorus

  • From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.

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Author:Leonidah Omosa Kerubo, Jacob Ogweno Midiwo, Solomon DereseORCiD, Moses K. Langat, Hoseah M. Akala, Norman C. Waters, Martin Peter, Matthias Heydenreich
ISSN:1934-578X (print)
Parent Title (English):Natural product communications : an international journal for communications and reviews
Place of publication:Westerville
Document Type:Article
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:Antiplasmodial activity; Asteraceae; Senecio roseiflorus; Surface exudates
First Page:175
Last Page:176
Funder:German Academic Exchange Service (DAAD); Deutsche Forschungsgemeinschaft, Germany [Pe 264/ 14-5]; Bundesministerium fur Zusammenarbeit [Pe-254/14-6]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert