Model-based Confirmation of Alternative Substrates of Mitochondrial Electron Transport Chain
- Background: There are alternative substrates to the mitochondrial respiration. Results: Data-driven model-based analysis renders predictions of alternative substrates to the mitochondrial respiration. Conclusion: Metabolomics data in conjunction with flux-based models can discriminate among hypotheses based on enzymology alone. Significance: This analysis provides a basic framework for in silico studies of alternative pathways in metabolism.
| Author details: | Sabrina Kleessen, Wagner L. Araujo, Alisdair R. FernieORCiDGND, Zoran NikoloskiORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1074/jbc.M111.310383 |
| ISSN: | 0021-9258 |
| Title of parent work (English): | The journal of biological chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Place of publishing: | Bethesda |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2012 |
| Publication year: | 2012 |
| Release date: | 2017/03/26 |
| Volume: | 287 |
| Issue: | 14 |
| Number of pages: | 10 |
| First page: | 11122 |
| Last Page: | 11131 |
| Funding institution: | Max-Planck Society; German Ministry of Science and Education [0313924] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
