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The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

  • The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL's protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may haveThe high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL's protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may have impact on HDL's biological functions, including cholesterol efflux capacity, antioxidative and anti-inflammatory activities. This review focuses on two molecules that affect the functionality of HDL. The balance between functional and dysfunctional HDL is disturbed after the loss of the protective sphingolipid molecule S1P and the accumulation of the acute-phase protein SAA. This review also summarizes the biological activities of lipid-free and lipid-bound SAA and its impact on HDL function.show moreshow less

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Metadaten
Author:Nicole Prüfer, Burkhard KleuserORCiDGND, Markus van der Giet
DOI:https://doi.org/10.1515/hsz-2014-0192
ISSN:1431-6730 (print)
ISSN:1437-4315 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25252751
Parent Title (English):Biological chemistry
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Review
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:atherosclerosis; high-density lipoprotein (HDL); inflammation; serum amyloid A (SAA); sphingosine-1-phosphate (S1P)
Volume:396
Issue:6-7
Pagenumber:11
First Page:573
Last Page:583
Funder:Deutsche Forschungsgemeinschaft; Else Kroner Fresenius Stiftung
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
Peer Review:Referiert