• search hit 1 of 1
Back to Result List

Formation of DNA-Copolymer Fibrils Through an Amyloid-Like Nucleation Polymerization Mechanism

  • Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.

Export metadata

Additional Services

Search Google Scholar Statistics
Metadaten
Author details:Dawid Kedracki, Sergey K. Filippov, Nidhi Gour, Helmut SchlaadORCiDGND, Corinne Nardin
DOI:https://doi.org/10.1002/marc.201400728
ISSN:1022-1336
ISSN:1521-3927
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/25704443
Title of parent work (English):Macromolecular rapid communications
Publisher:Wiley-VCH
Place of publishing:Weinheim
Publication type:Article
Language:English
Year of first publication:2015
Publication year:2015
Release date:2017/03/27
Tag:DNA copolymers; fibers; hydrogen bonding; nucleation polymerization; self-assembly
Volume:36
Issue:8
Number of pages:6
First page:768
Last Page:773
Funding institution:ESRF; Diamond Light Source; University of Geneva; Swiss National Science Foundation for Research [PPOOP2-12838]; BiostructX [6019]; [INGO LG13058]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer review:Referiert
Accept ✔
This website uses technically necessary session cookies. By continuing to use the website, you agree to this. You can find our privacy policy here.