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Antiplasmodial and larvicidal flavonoids from Derris trifoliata

  • From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.

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Author:Martin G. Peter, Abiy Yenesew, Hannington Twinomuhwezi, Jacques M. Kabaru, Hoseah M. Akala, Bernard T. Kiremire, Matthias Heydenreich, Fredrick Eyase, Norman C. Waters, Douglas S. Walsh
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 121)
Document Type:Postprint
Year of Completion:2009
Publishing Institution:Universität Potsdam
Release Date:2010/07/06
Tag:(S)-Lupinifolin 4´-methyl ether; Derris trifoliata; Flavanone; Leguminosae; Lupinifolin
Source:Bulletin of the Chemical Society of Ethiopia 23 (2009), 3, S. 409 - 414
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:
The article was originally published by:
The Chemical Society of Ethiopia
Bulletin of the Chemical Society of Ethiopia. - 23 (2009), 3, S. 409-414
ISSN 1011-3924