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Naphthoquinones from the roots of Aloe secundiflora

  • Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21-23 mu g/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mu g/mL).

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Author details:Martha Induli, Michael Cheloti, Antonina Wasuna, Ingrid Wekesa, John M. Wanjohi, Robert Byamukama, Matthias Heydenrich, Moses Makayoto, Abiy YenesewORCiD
DOI:https://doi.org/10.1016/j.phytol.2012.04.014
ISSN:1874-3900
Title of parent work (English):Phytochemistry letters
Publisher:Elsevier
Place of publishing:Amsterdam
Publication type:Article
Language:English
Year of first publication:2012
Publication year:2012
Release date:2017/03/26
Tag:5-Hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione 5,8-Dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione; Aloe secundiflora; Aloesaponarin I; Anthraquinone; Asphodelaceae; Mycobacterium tuberculosis; Naphthoquinone; Roots
Volume:5
Issue:3
Number of pages:4
First page:506
Last Page:509
Funding institution:German Academic Exchange Services (DAAD) through the Natural Products Research Network for Eastern and Central Africa (NAPRECA); Kenya Industrial Research and Development Institute (KIRDI)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer review:Referiert
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