3-Oxo-14 alpha, 15 alpha-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides
- The stem bark extract of Schizozygia coffaeoides (Apocynaceae) showed moderate antiplasmodial activity (IC50 = 8-12 mu g/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new schizozygane indoline alkaloid, named 3-oxo-14 alpha, 15 alpha-epoxyschizozygine. In addition, two dimeric anthraquinones, cassiamin A and cassiamin B, were identified for the first time in the family Apocynaceae. The structures of the isolated compounds were deduced on the basis of spectroscopic evidence. The schizozygane indole alkaloids showed good to moderate antiplasmodial activities (IC50 = 13-52 mu m). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
| Author details: | Yoseph Atilaw, Matthias HeydenreichORCiD, Albert NdakalaORCiD, Hoseah M. AkalaORCiD, Edwin Kamau, Abiy YenesewORCiD |
|---|---|
| DOI: | https://doi.org/10.1016/j.phytol.2014.07.003 |
| ISSN: | 1874-3900 |
| ISSN: | 1876-7486 |
| Title of parent work (English): | Phytochemistry letters |
| Publisher: | Elsevier |
| Place of publishing: | Amsterdam |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2014 |
| Publication year: | 2014 |
| Release date: | 2017/03/26 |
| Tag: | 3-Oxo-14 alpha, 15 alpha-epoxyschizozygine; Cassiamin A; Cassiamin B; Dimeric anthraquinone; Schizozygane indoline alkaloid; Schizozygia coffaeoides |
| Volume: | 10 |
| Number of pages: | 4 |
| First page: | 28 |
| Last Page: | 31 |
| Funding institution: | German Academic Exchange Services (DAAD) through Natural Products Research Network for Eastern and Central Africa (NAPRECA); International Science Program (ISP, Sweden) [KEN-02] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
