The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 41 of 2279
Back to Result List

The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality

  • The high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL's protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may haveThe high-density lipoprotein (HDL) is one of the most important endogenous cardiovascular protective markers. HDL is an attractive target in the search for new pharmaceutical therapies and in the prevention of cardiovascular events. Some of HDL's anti-atherogenic properties are related to the signaling molecule sphingosine-1-phosphate (S1P), which plays an important role in vascular homeostasis. However, for different patient populations it seems more complicated. Significant changes in HDL's protective potency are reduced under pathologic conditions and HDL might even serve as a proatherogenic particle. Under uremic conditions especially there is a change in the compounds associated with HDL. S1P is reduced and acute phase proteins such as serum amyloid A (SAA) are found to be elevated in HDL. The conversion of HDL in inflammation changes the functional properties of HDL. High amounts of SAA are associated with the occurrence of cardiovascular diseases such as atherosclerosis. SAA has potent pro-atherogenic properties, which may have impact on HDL's biological functions, including cholesterol efflux capacity, antioxidative and anti-inflammatory activities. This review focuses on two molecules that affect the functionality of HDL. The balance between functional and dysfunctional HDL is disturbed after the loss of the protective sphingolipid molecule S1P and the accumulation of the acute-phase protein SAA. This review also summarizes the biological activities of lipid-free and lipid-bound SAA and its impact on HDL function.show moreshow less

Export metadata

Additional Services

Search Google Scholar Statistics
Metadaten
Author details:Nicole Prüfer, Burkhard KleuserORCiDGND, Markus van der Giet
DOI:https://doi.org/10.1515/hsz-2014-0192
ISSN:1431-6730
ISSN:1437-4315
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/25252751
Title of parent work (English):Biological chemistry
Publisher:De Gruyter
Place of publishing:Berlin
Publication type:Review
Language:English
Year of first publication:2015
Publication year:2015
Release date:2017/03/27
Tag:atherosclerosis; high-density lipoprotein (HDL); inflammation; serum amyloid A (SAA); sphingosine-1-phosphate (S1P)
Volume:396
Issue:6-7
Number of pages:11
First page:573
Last Page:583
Funding institution:Deutsche Forschungsgemeinschaft; Else Kroner Fresenius Stiftung
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
Peer review:Referiert
Accept ✔
This website uses technically necessary session cookies. By continuing to use the website, you agree to this. You can find our privacy policy here.