Scaling Up UV-Mediated Intramolecular Photodehydro-Diels-Alder Reactions Using a Homemade High-Performance Annular Continuous-Flow Reactor
- Here we present a self-made annular continuous-flow reactor that can be used in the UV/vis range in an internal numbering-up manner. As a model reaction, we chose a powerful batch-scale-limited benzoannelation method, namely, an intramolecular photodehydro-Diels-Alder (IMPDDA) reaction. The scale-up potential of this particular photochemical benchmark reaction toward the preparation of macrocylic (1,7)naphthalenophanes by variation of selected flow parameters is presented.
| Author details: | Maciej CzarneckiORCiD, Pablo WessigORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1021/acs.oprd.8b00353 |
| ISSN: | 1083-6160 |
| ISSN: | 1520-586X |
| Title of parent work (English): | Organic Process Research & Development |
| Publisher: | American Chemical Society |
| Place of publishing: | Washington |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2018/11/20 |
| Publication year: | 2018 |
| Release date: | 2021/01/13 |
| Tag: | flow photochemistry; photocycloaddition; photodehydro-Diels-Alder reaction; scale-up |
| Volume: | 22 |
| Issue: | 12 |
| Number of pages: | 5 |
| First page: | 1823 |
| Last Page: | 1827 |
| Funding institution: | Deutsche Forschungsgemeinschaft |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
| License (German): |  Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
